英文化学名:Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate, SNAC 中文学名:沙波立沙钠 英文学名:Salcaprozate sodium 分子式:C15H20NNaO4 分子量:301.32 CAS No. : 203787-91-1 已以合作工厂名义做了药用辅料登记备案,可成吨供应大货 关键字: 8-(2-羟基苯甲酰氨基]辛酸钠;SNAC;203787-91-1;沙波...
先说什么是中间体SNAC:即Sodium N-(8-[2-hydroxybenzoyl] Amino) Caprylate,8-(2-羟基苯甲酰胺基)辛酸钠,是一种氨基酸衍生物吸收促进剂,能促进肝素及人生长激素等多种蛋白质类药物溶液的口服吸收。在招股书中没有提到下游药企诺和诺德,提到了礼来等,但金凯生科8月11日在互动平台表示,公司为诺和诺德的司美格鲁...
1、snac(sodium n-[8-(2-hydroxybenzoyl)amino]caprylate),即n-(8-[2-羟基苯甲酰基]-氨基)辛酸钠,其结构式如下: 2、一种合成的两性水杨酸的n-乙酰化氨基酸衍生物,是目前最先进的肠渗透促进剂(pes),可与多肽一同粘附在胃粘膜上,从而促进药物渗透吸收,被广泛用作口服药物制剂的递送剂。 3、snac最早是由e...
The present invention relates to a method of making sodium N-(8-2-Hydroxybenzoyl)amino caprylate form A, SNAC polymorphic form A having improved stability and the use of said SNAC polymorphic form A in a solid pharmaceutical dosage form-...
中文名:N-(8-(2-hydroxybenzoyl)amino)caprylate,英文名:N-(8-(2-hydroxybenzoyl)amino)caprylate,CAS:,MSDS.
In four cohorts of 28, 21, 19 and 29 healthy volunteers, the impact of the carrier molecule sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC, CAS number: 203787-91-1) on the bioavailability of IBN was investigated. Within each cohort different oral formulations with one dose of ...
Pathway of Oral Absorption of Heparin with Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate PURPOSE: The oral bioavailability of heparin is negligible. Recent studies, however, have shown that sodium N-[8-(2-hydroxybenzoyl) amino]caprylate (SNAC) ... D Malkov,HZ Wang,S Dinh,... - 《Pharm ...
sodium,8-[(2-hydroxybenzoyl)amino]octanoate8-(2-羟基苯甲酰胺基)辛酸钠203787-91-1 N-Methyl-D-glucamine葡甲胺6284-40-8 6-(2-methyl-2-propenyl)imidazo[1,2-a]pyridine6-(2-甲基-2-烯丙基)咪唑并[1,2-a]吡啶116355-20-5 oxyphenisatine di(acetate)双醋酚丁115-33-3 ...
Investigation of the enhancing mechanism of sodium n-[8-(2-hydroxybenzoyl)amino]caprylate effect on the intestinal permeability of polar molecules utilizing a voltage clamp method. Hess,S.,Rotshild,V.,Hoffman,A. European Journal of Pharmaceutical Sciences . 2005...
This study was conducted to investigate whether the excipient SNAC (sodium N-[8-(2-hydroxybenzoyl)amino] caprylate) needs to be co-formulated or just co-dosed in order to increase the oral bioavailability of ibandronate (IBN). This was a single-dose, open-label, crossover study in 52 ...