Muscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and flexible protein that is tightly bound to the thick filament at its C-terminal end (MyBP-C), but may be loosely ...
stunningmodelincanineheart.Car-diacmyosinbindingproteinC(cMyBP-C),aregulatorymyofilamentproteinassociatedwiththethickfilament,andnebulette,athinfilamentassociatedprotein,weredifferentiallyexpressed.Phosphoproteinspecificstainingindicatedbothproteinchangeswereduetophosphorylation.SubsequentphosphorylationmappingofcaninecMyBP-Cusing...
Myosin Binding Protein-C slow (sMyBP-C), encoded byMYBPC1, comprises a family of regulatory proteins of skeletal muscles that are phosphorylated by PKA and PKC.MYBPC1missense mutations are linked to the development of Distal Arthrogryposis-1 (DA-1). Although structure-function details for thi...
Lu Y, Kwan AH, Jeffries CM, Guss JM, Trewhella J (2012) The motif of human cardiac myosin-binding protein C is required for its Ca2+-dependent interaction with calmodulin. J Biol Chem 287: 31596-31607.Lu, Y., Kwan, A. H., Jeffries, C. M., Guss, J. M., and Trewhella, J....
A myosin-binding protein is identified that mediates the low ionic strength solubility of myosin in extracts of unfertilized sea urchin eggs. The protein, termed 53K, possesses a subunit molecular weight on SDS-PAGE of 53 kD and an S value of 7. The association between myosin and 53K is ...
Lifelong Left Ventricular Remodeling of Hypertrophic Cardiomyopathy Caused by a Founder Frameshift Deletion Mutation in the Cardiac Myosin-Binding Protein C Gene Among Japanese Author links open overlay panelToru Kubo MD ⁎, Hiroaki Kitaoka MD, PhD ⁎, Makoto Okawa MD ⁎, Yoshihisa Matsumura MD,...
This exceptional case underscores the remarkable ability of the heart muscle to show a continuous hypertrophic process over many years. 展开 关键词: Hypertrophy Myosin-binding protein C Mutation DOI: 10.1016/j.ijcard.2005.01.004 被引量: 5 年份: 2005 ...
Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA). Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase anchoring proteins (AKAPs). Cardiac Myosin Binding Protein-C (cMyBPC...
A Gain-of-Function Mutation in the M-domain of Cardiac Myosin-binding Protein-C Increases Binding to Actin The M-domain is the major regulatory subunit of cardiac myosin-binding protein-C (cMyBP-C) that modulates actin and myosin interactions to influence muscle... KL Bezold,JF Shaffer,JK Kh...
阅读量: 7 作者: M Gupta,J Gulick,J Robbins 展开 摘要: Despite early demonstrations of myosin binding protein C's (MyBP-C) interaction with actin, different investigators have reached different conclusions regarding the relevant and necessary domains mediating this binding. Establishing the deta...