Myosin-binding protein-C (cMyBP-C) is a key regulator of contractility in heart muscle, and its regulatory function is controlled in turn by phosphorylation of multiple serines in its m-domain. The structural and functional effects of m-domain phosphorylation have often been inferred from those ...
Gurnett, C. A. et al. Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. Human molecular genetics 19, 1165–1173, 10.1093/hmg/ddp587 (2010). ArticleCASPubMedPubMed CentralGoogle Scholar Hall, J. G. Genetic aspects of arthrogryposis. Clinical orthopaed...
Gurnett, C. A.et al. Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1.Hum Mol Genet, 1165–1173,https://doi.org/10.1093/hmg/ddp587(2010). Google Scholar Markus, B.. Autosomal recessive lethal congenital contractural syndrome type 4 (LCCS4) caused...
The unique myosin binding protein-c "motif" near the N-terminus of myosin binding protein-C (MyBP-C) binds myosin S2. Previous studies demonstrated that recombinant proteins containing the motif and flanking regions (e.g., C1C2) affect thin filament movement in motility assays using heavy mero...
Protein descriptionProtein (n)pCa50 before proteinpCa50 after proteinΔpCa50nH before proteinnH after protein Wild-type C1C2 (9) 5.70 ± 0.01 6.00 ± 0.01a 0.29 ± 0.09 4.82 ± 0.56 2.56 ± 0.07a Residues near phosphorylation sites R270A,R271A (6) 5.63 ± 0.01 5.72 ± 0.02a 0.08 ±...
Cardiac myosin binding protein-C is a protein expressed in the myosin thick filament backbone that was recently described as a novel cardiac biomarker. Its N-terminal region, C0-C1f, is released within the first minutes of ischemia and plays a crucial role in the initiation of inflammation in...
Cardiac Myosin Binding Protein-C (cMyBPC) and cardiac troponin I (cTNI) are hypertrophic cardiomyopathy (HCM)-causing sarcomeric proteins which regulate contractility in response to PKA phosphorylation. Results During a yeast 2-hybrid (Y2H) library screen using a trisphosphorylation mimic of the C1-...
Myosin-Binding Protein C (MyBP-C) in Cardiac Muscle and Contractility Both the MyBP-C motif between C1 and C2 and the C5 module are important regions for implementing the effect of MyBP-C on myosin and on contractility but in... S Winegrad - 《Oxygen Transport to Tissue XXXIII》 被引...
(see Figure1forxi-1). It has been shown previously that no XI-K protein is produced in thexi-kmutant, although the corresponding mRNA was present [19]. Inxi-1mutant, the T-DNA is inserted into the coding region; thus, we assumed that no functional XI-1 protein can be produced in ...
titin and myosin-binding protein C (MyBP-C). The arrangement of myosin molecules is dependent on their position along the filament, suggesting specialized capacities in terms of strain susceptibility and force generation. Three pairs of titin-α and titin-β chains run axially along the filament,...