Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function ...
Myosin-binding protein C (MyBP-C) is a multidomain protein present in the thick filaments of striated muscles and is involved in both sarcomere formation and contraction regulation, The latter function is believed to be located at the N terminus, which is close to the motor domain of myosin...
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Myosin binding protein-C (MyBP-C) is a striated muscle protein that regulates contraction and consists of three isoforms known as slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C, and cMyBP-C), encoded byMYBPC1,MYBPC2andMYBPC3, respectively1,2,3. As their names would s...
Thus, while the importance of studying this cardiac sarcomere protein is clear, preliminary data in the literature have raised many questions. Therefore, in this article, we propose to review the structure and function of cMyBP-C with particular respect to the role(s) in cardiac contractility ...
建议收到该Myosin Binding Protein C, Slow Type (MYBPC1) Antibody产品后,储存温度为-20°C。避免重复冻融 其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、...
Myosin Binding Protein-C slow (sMyBP-C), encoded byMYBPC1, comprises a family of regulatory proteins of skeletal muscles that are phosphorylated by PKA and PKC.MYBPC1missense mutations are linked to the development of Distal Arthrogryposis-1 (DA-1). Although structure-function details for thi...
Cardiac myosin binding protein-C: redefining its structure and function Biophys Rev, 4 (2012), pp. 93-106 Google Scholar 8 J.O. Baker, R. Tyther, C. Liebetrau, et al. Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury Basic Res Cardiol, 110 (2015), p...
Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studi...
Mutations in the MYBPC3 gene encoding human cardiac myosin-binding protein-C (cMyBP-C) are associated with familial hypertrophic cardiomyopathy (FHC), but the molecular mechanisms involved are not fully understood. In addition, development of FHC is sensitive to genetic background, and the search ...