Myocardial ischemia-reperfusion injury is a complex and common cardiovascular disease with a multifaceted mechanism of occurrence. Typically, the mechanism of myocardial ischemia-reperfusion injury can be divided into two phases: the ischemic phase and the reperfusion phase [16]. During the ischemic phas...
Ischemia heart disease continues to be the leading cause of human disability and mortality worldwide1. Early coronary reperfusion is the most effective strategy to alleviate the ischemic injury; however, reperfusion itself may lead to additional myocardial injury, a phenomenon known as ischemia/...
Reactive oxygen species (ROS) contribute to myocardial death during ischemia-reperfusion (I/R) injury, but detailed knowledge of molecular pathways connecting ROS to cardiac injury is lacking. Activation of the Ca2+/calmodulin-dependent protein kinase II (CaMKIIδ) is implicated in myocardial death, ...
This disorder in phospholipid metabolism is felt to be the critical lesion that produces irreversible cell injury in ischemia. It affects the endoplasmic and sarcoplasmic reticular membranes of liver and myocardial cells, respectively, and probably the plasma membranes of both. It is prevented by ...
To investigate the protective effects of Cinepazide Maleate on myocardial ischemiareperfusion injury during open heart surgery. 目的探讨马来酸桂哌齐特在体外循环心内直视手术中对心肌缺血再灌注损伤的保护作用。 word.hcbus.com 2. Objective To investigate the effect of Shenfu injection(SFI) on myocardial isc...
The present study aimed to assess the effects and mechanisms of genistin in the rat model of myocardial ischemia reperfusion injury. The rat hearts were ex... Meng,Gu,Ai-Bin,... - 《Evidence Based Complementary & Alternative Medicine Ecam》 被引量: 7发表: 2016年 Cardioprotective effects of ...
1)Myocardial ischemia/reperfusion injury心肌缺血/再灌注损伤 1.Recent studies indicate that cell apoptosis is closely related to myocardial ischemia/reperfusion injury, and may be involved in its pathogenesis.近年研究发现细胞凋亡与心肌缺血/再灌注损伤关系密切,可能是其发病机制之一。 2.Objective:To investiga...
Myocardial ischemia-reperfusion injury is the injury that emaciates from detrimental impacts of intracellular calcium and oxidative stress, which...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough homework ...
Troponin levels were correlated with lower myocardial oxygen supply and impaired myocardial oxygen supply–demand balance, suggesting that subendocardial ischemia might contribute to myocyte injury. Troponin elevation in HFpEF was associated with limitations in LV systolic and diastolic reserve, as well ...
M. Myocardial ischemia–reperfusion injury: a neglected therapeutic target. J. Clin. Invest. 123, 92–100 (2013). CAS Google Scholar Moran, A. E. et al. The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study. Circulation 129, 1493–1501 ...