Myocardial infarction, ischemia-reperfusion, or sham surgery was performed in adult mice through permanent or temporary ligation (60 min) of the left anterior descending artery (LAD). Mice were anesthetized by an intraperitoneal injection of a Fentanyl (50 μg/kg), Midazolam (5 mg/kg),...
Myocardial infarction (MI) or myocardial ischemia/reperfusion (MI/R) injury Park et al. revealed that myocardial ferroptosis occurs during MI [87]. Subsequently, they used Western blot analysis and RNA sequencing (RNA-seq) to demonstrate that the expression of GPX4 was declining in the early (M...
ArticleGoogle Scholar Nuntaphum, W.et al.Vagus nerve stimulation exerts cardioprotection against myocardial ischemia/reperfusion injury predominantly through its efferent vagal fibers.Basic Res. Cardiol. (Internet)113(4), 1–20.(2018). Sevcencu, C., Nielsen, T. N. & Struijk, J. J. An intra...
21 Myocardial scarring owing to a previous MI may be a substrate for arrhythmias,15 and myocardial ischemia can be one of the triggering factors. Indeed, there is evidence that myocardial scarring has been associated with SCD during physical exercise,22 which was also observed in these data. ...
Myocardial metabolism, Myocardial ischemia, myocardial perfusion, Myocardial adenine nucleotide metabolism,Origins of Cardiovascular Disease,Prosthesis-Patient Mismatch (PPM) in TAVI vs SAVR,Pulmonary Valve Replacement and Repair,TAVI vs Open Heart Surgery,Thoracic Aorta,Transcatheter Aortic Valve Replacement ...
There is some recent evidence that cardiac ischemia/reperfusion (I/R) injury induces intestinal damage within days, which contributes to adverse cardiovascular outcomes after myocardial infarction. However, it is not clear whether remote gut injury has any detectable early signs, and whether different ...
Acute myocardial infarction due to acute myocardial ischemia results in severe systolic and diastolic dysfunction of the heart with elevation in left ventricular end-diastolic pressure (LVEDP), PCWP, pulmonary edema, decrease in stroke volume, and low cardiac output [88]. Therefore, the aim of trea...
Cardiomyocytes express and secrete GDF-15 after stimulated ischemia and reperfusion in mice, and endogenous GDF-15 protects the heart from ischemic injury [32]. Thus, detection of elevated levels of GDF5 and cTnI confirmed cardiac damage in our LPS model. In our next approach, we analyzed the...
et al. Duration of ischemia is a major determinant of transmurality and severe microvascular obstruction after primary angioplasty: a study performed with contrast-enhanced magnetic resonance. J. Am. Coll. Cardiol. 46, 1229–1235 (2005). Article PubMed Google Scholar Francone, M. et al. Im...
Thus, chronic ischemia significantly alters the cardiac proteome, yet the infarcted heart remains malleable and responsive to CP cell treatment. Fig. 1: Cardiopoietic cell therapy reduces infarction altered cardiac proteome. a Of the 3987 identified ventricular proteins, 450 (11.3%) differed ...