Myocardial infarction (MI) or myocardial ischemia/reperfusion (MI/R) injury Park et al. revealed that myocardial ferroptosis occurs during MI [87]. Subsequently, they used Western blot analysis and RNA sequencing (RNA-seq) to demonstrate that the expression of GPX4 was declining in the early (M...
Myocardial infarction, ischemia-reperfusion, or sham surgery was performed in adult mice through permanent or temporary ligation (60 min) of the left anterior descending artery (LAD). Mice were anesthetized by an intraperitoneal injection of a Fentanyl (50 μg/kg), Midazolam (5 mg/kg), ...
21 Myocardial scarring owing to a previous MI may be a substrate for arrhythmias,15 and myocardial ischemia can be one of the triggering factors. Indeed, there is evidence that myocardial scarring has been associated with SCD during physical exercise,22 which was also observed in these data. ...
This suggests that postoperative troponin elevation involves enhanced cell permeability as seen after ischemia reperfusion rather than permanent cellular damage. The gentler down-slope may point to surgery-induced impaired troponin removal from the circulation. Due to the different mechanisms proposed, ...
The prevalence and type of ischemia (silent vs painful) in survivors of cardiac arrest not associated with acute myocardial infarction were studied to test the hypothesis that survivors may have an increased prevalence of silent ischemia. Of 48 survivors of cardiac arrest over a 4-year period who...
Fifty percent of patients presented with potential signs of ischemia on the ECG. Ischemic ECG changes alone seem to be a poor marker of the presence of a culprit lesion.22The absence of benefit of an emergent CAG strategy may, therefore, be attributable to the low rate of acute lesions. ...
There is some recent evidence that cardiac ischemia/reperfusion (I/R) injury induces intestinal damage within days, which contributes to adverse cardiovascular outcomes after myocardial infarction. However, it is not clear whether remote gut injury has any detectable early signs, and whether different ...
In a recent study, among patients with INOCA, those with impaired myocardial perfusion reserve had the highest cardiac troponin-I (cTnI) and worse diastolic function [11]. These observations have led to the hypothesis that in INOCA microvascular dysfunction leads to ischemia-mediated cardiomyocyte ...
et al. Duration of ischemia is a major determinant of transmurality and severe microvascular obstruction after primary angioplasty: a study performed with contrast-enhanced magnetic resonance. J. Am. Coll. Cardiol. 46, 1229–1235 (2005). Article PubMed Google Scholar Francone, M. et al. Im...
Thus, chronic ischemia significantly alters the cardiac proteome, yet the infarcted heart remains malleable and responsive to CP cell treatment. Fig. 1: Cardiopoietic cell therapy reduces infarction altered cardiac proteome. a Of the 3987 identified ventricular proteins, 450 (11.3%) differed ...