MI, resuscitated cardiac arrest, or hospitalization for unstable angina or heart failure. A major secondary endpoint is CV death or MI. Other secondary endpoints include the individual
Adverse cardiac outcomes In both hospitals two postoperative ischemic cardiac complications were included as adverse outcomes: (1) cardiac death as a result of myocardial infarction, congestive heart failure, or arrhythmia; and (2) myocardial infarction, based on the existence of at least two of the...
TRPV4 antagonist HC-067047 reduces myocardial infarction and improves cardiac function after I/R. Since myocardial I/R caused the TRPV4 up-regulation, we then sought to determine whether TRPV4 up-regulation plays an important role in myocardial I/R injury. For this, we used HC-067047, a...
Over a median of 3.3 years follow-up, Kaplan-Meier curves for the primary endpoint — a composite of cardiovascular (CV) death, myocardial infarction (MI), hospitalization for unstable angina, hospitalization for heart failure, or resuscitated cardiac arrest — were similar between the invasive and...
The paradoxical observation that reoxygenation enhances cell and tissue injury has perplexed investigators for over a century. Disorders characterized by chronic and acute reductions inorgan blood flowand I/R injury include myocardial infarction and stroke.64The I/R undergone by transplanted organs shares...
Cardiac Biomarkers and their Importance in the Diagnosis of Myocardial Ischemia and Acute Myocardial Infarction Coronary artery disease (CAD) is the leading killer disease worldwide. There are various biophysical techniques including invasive and non-invasive methods... A Munta,V Raghavan,RM Gorle,.....
Reactive oxygen species (ROS) contribute to myocardial death during ischemia-reperfusion (I/R) injury, but detailed knowledge of molecular pathways connecting ROS to cardiac injury is lacking. Activation of the Ca2+/calmodulin-dependent protein kinase II
This cohort study examines the frequency of acute infarction defined by diffusion restriction detected on magnetic resonance imaging scans among patients
Myocardial ischemia is characterized by an imbalance between myocardial oxygen supply and demand, causing cardiac dysfunction, arrhythmias, myocardial infarction, and sudden death. Various clinical ischemic manifestations are caused by obstruction of coronary blood flow by coronary stenosis, thrombosis, and/...
1C-D). Furthermore, to explore the consequences of the DUSP1 downregulation in cardiac IR injury, DUSP1TG mice were subjected to an IR injury (2-h ischemia and 6-h reperfusion), and the degree of infarction was quantified, demonstrating a significant reduction in infarction area compared ...