A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multiple myeloma, these cells multiply the wrong way. They let too much protein (called immunoglobulin) into your bones and blood. It builds up throughout your body and damages...
myelomaprognosis112 patients with multiple myeloma have been studied at diagnosis for the presence of blood clonal B-cell excess (CBE), defined as a ratio between k+ and 位+ lymphocytes outside the normal range (0.9-3.5). 48 patients (43%) had CBE. The increase in light chain-bearing ...
Diagnosis MM is often discovered through routine blood screening when patients are being evaluated for unrelated problems. In one third of patients, the condition is diagnosed after a pathologic fracture occurs, usually involving the axial skeleton. Examination for MM may reveal the following: Fundos...
For patients: the diagnosis of symptomatic multiple myeloma was done by bone marrow aspirate ± biopsy for evaluation of plasma cell infiltration, immunophenotyping, flow cytometry, protein electrophoresis, immunofixation electrophoresis, and serum free light chain measurements (done in limited number ...
Blood Cancer Journal(2025) Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia Thierno D. Diallo Ariane Irma Luise Blessing Jakob Neubauer Skeletal Radiology(2025) Isatuximab plus pomalidomide and dexamethasone in frail individuals with relapsed/refractory multiple myeloma in...
3). To mimic the clinical scenario of MM diagnosis, once MM reaches 10% of the bone marrow area in silico, treatment is applied either continuously (as for mouse models of multiple myeloma) or pulsed (2 weeks on, 1 week off; as is performed in the clinic) until MM burden reaches 20...
After removing contaminating cell types, we reprocessed our data prior to downstream analyses. Despite removing clusters of red blood cells, we still detected ambient contamination of hemoglobin genes in some samples, and thus we regressed out a "hemoglobin score," computed as the mean of log-norm...
(MC) from random BM and intramedullary focal lesion aspirates as well as from peripheral blood (PB) were isolated using the Ficoll–Paque method. Subsequently, BM MM cells were enriched using an immuno-magnetic CD138-positive selection (Robosep, Stemcell Technologies). The CD138-positive and ...
Van Oekelen, O., Birrer, N., Wesson, W.et al.Characteristics of measurable residual disease assessment in myeloma: a review of clinical trials from 2015–2020.Blood Cancer J.12, 155 (2022). https://doi.org/10.1038/s41408-022-00750-1 ...
sMM PCs from 33 patients and MM PCs from 170 patients at diagnosis. Student’sttest: NS non significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (*compared to healthy;#compared to MGUS;$compared to SMM). right: Bar chart showing the percentage of ...