A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multiple myeloma, these cells multiply the wrong way. They let too much protein (called immunoglobulin) into your bones and blood. It builds up throughout your body and damages...
doi:10.1097/01.COT.0000544336.55001.caOvid Technologies (Wolters Kluwer Health)Oncology Times
Presenting signs and symptoms of multiple myeloma (MM) include bone pain, pathologic fractures, weakness, anemia, infection (often pneumococcal), hypercalcemia, spinal cord compression, and renal failure. In approximately 30% of cases, MM is discovered through routine blood screening when patients are...
Blood Cancer Journal volume 14, Article number: 69 (2024) Cite this article 9198 Accesses 8 Citations 39 Altmetric Metrics details Abstract In the MASTER study (NCT03224507), daratumumab+carfilzomib/lenalidomide/dexamethasone (D-KRd) demonstrated promising efficacy in transplant-eligible newly diagnosed...
After removing contaminating cell types, we reprocessed our data prior to downstream analyses. Despite removing clusters of red blood cells, we still detected ambient contamination of hemoglobin genes in some samples, and thus we regressed out a "hemoglobin score," computed as the mean of log-norm...
More intensive therapy has a better effect for frail parents with multiple myeloma[J].Blood Adv, 2023,7(20):6275-6284. [26] Augustson BM, Begum G, Dunn JA, et al. Early mortality after diagnosis of multiple myeloma: analysis of patients entered onto the United Kingdom Medical Research ...
3). To mimic the clinical scenario of MM diagnosis, once MM reaches 10% of the bone marrow area in silico, treatment is applied either continuously (as for mouse models of multiple myeloma) or pulsed (2 weeks on, 1 week off; as is performed in the clinic) until MM burden reaches 20...
Newly diagnosis MM HSPC: Hematopoietic stem and progenitor cell GMP: Granulocyte–monocyte progenitor nPCs: Normal plasma cells IFN: Interferon RRMM: Relapsed/refractory MM NMF: Non-negative matrix factorization CNA: Copy number alteration OS: Overall survival PFS: Progression-free survival...
Risk stratification for clotting should occur at diagnosis, and most patients will require direct oral anticoagulant prophylaxis rather than aspirin alone to mitigate immunomodulatory drug-associated clot risk. Lastly, given the emergence of exciting novel therapies like chimeric antigen receptor T-cell ...
Mononuclear cells (MC) from random BM and intramedullary focal lesion aspirates as well as from peripheral blood (PB) were isolated using the Ficoll–Paque method. Subsequently, BM MM cells were enriched using an immuno-magnetic CD138-positive selection (Robosep, Stemcell Technologies). The CD138...