Introduction: Myelodysplastic syndrome (MDS) is driven by aberrant hematopoietic stem and progenitor cells and, therefore, affects the cellular constitution of bone marrow. While it is known that cell proportion
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively im
Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors Nat. Nanotechnol.(2025). https://doi.org/10.1038/s41565-024-01847-3 在本研究中,我们提出了一种基于天然脂蛋白的纳米技术平台,旨在将小干扰RNA(siRNA)、反义寡核苷酸和信使RNA(mRNA)递送至骨髓中...
In subject area: Medicine and Dentistry Myeloid cells are a family of immune cells comprising monocytes, macrophages, myeloid dendritic cells (mDCs), granulocytes, and mast cells that originate from a common myeloid progenitor in the bone marrow. ...
bone marrow. These changes subsequently determine the function of the myeloid cells in circulation and organs. While in the case of infections or vaccinations such processes (also called ‘trained immunity’) improve the function of myeloid cells9,10, one could hypothesize that opposite effects ...
Bone cancer Bone marrow cells Metastasis Osteoimmunology References Valastyan, S., & Weinberg, R. A. (2011). Tumor metastasis: molecular insights and evolving paradigms.Cell, 147, 275–292. ArticleCASPubMedPubMed CentralGoogle Scholar Marie, P. (1997). Growth factors and bone formation in ost...
myeloid cells include macrophages, monocytes, granulocytes, and DCs. Thus, the question needs to be raised as to at which point the putative precommitment to a certain cell lineage truly takes place in the mammalian bone marrow. A potential answer might be that the HSC pool is more heterogeneou...
NTS treatment stimulates myeloid colony forming capacity in patient bone marrow cells.Marije BartelsAndrana K. CalgarottoAnton C. MartensVictor MasoSaulo L. da SilvaMarc B. BieringsMary L. de Souza QueirozPaul J. Coffer
myeloid-derived suppressor cells; TEMs, Tie2-expressing macrophages; DCs, dendritic cells; IL, interleukin; VEGF, vascular endothelial growth factor; TNF, tumor necrosis factor; TGF, transforming growth factor; IFN, interferon; MMP, matrix metalloproteinase Metastasis is a key step in cancer progressi...
Chronic myeloid leukemia (CML) is characterized by abnormal proliferation of myeloid cells which when untreated leads to bone marrow failure. Imatinib mesylate (IM) is the first line of therapy for treatment of CML and results in remission in most cases.