选择了两个特定基因集 HALLMARK_MYC_TARGETS_V1 和 HALLMARK_ALLOGRAFT_REJECTION 作为标志基因集中过程的示例,这些基因集与以 GSEA p值约为 0.05 为特征的乳腺癌队列中的表型相关(对于 MYC_TARGETS_V1 和p = 0.0684,p = 0.0172 和p = 0.0684)对于 ALLOGRAFT_REJECTION)。两个基因组的标准ES 的零分布显示在富...
The invention discloses a catalog of targets of the myc oncogene family identified by Serial Analysis of Gene Expression. The invention also discloses a method for analyzing myc downstream targets in view of the full context of myc induced changes in gene expression. The invention further disclose...
参考报价:￥1 - 4800 品牌:英拜生物 产地:上海 型号:MYC靶标基因PCR芯片MYC Targets PCR Array 样本:来电或留言获取样本 在线咨询 留言咨询 电话咨询 收藏 AI问答 MYC靶标基因PCR芯片MYCTargetsPCRArray价格? 可以检测什么? MYC靶标基因PCR芯片MYCTargetsPCRArray参数规格? 配套的耗材试剂? MYC靶标基因PCR芯片...
简介:MYC Targets PCR Array 提供商:SAB 服务名称:MYC Targets PCR Array Human MYC Targets PCR Array The Human MYC Targets RT² Profiler PCR Array profiles the expression of 84 key cancer-related genes controlled by a major oncogenic transcription factor. MYC contains a basic helix-loop-helix DNA...
然后使用TAG衍生的排序来驱动基因集富集分析(GSEA),在Hallmark基因集上进行,克隆复杂性的降低与Myc信号直接相关(Myc Targets V1和E2F靶点紧随Myc靶点V2,p < 10-5,图4B,C)。这个结果是非常有意义的,因为Myc信号传导是涉及细胞-细胞竞争的少数已描述的机制之一。Myc表达本身是超级竞争者克隆的特征,与Shannon熵显著...
The invention discloses a catalog of targets of the myc oncogene family identified by Serial Analysis of Gene Expression. The invention also discloses a method for analyzing myc downstream targets in view of the full context of myc induced changes in gene expression. The invention further disclose...
MYC-driven transcriptional program enriched in gene sets related to cell proliferation (E2F_targets, G2M_chekpoint) or MYC-transcriptional activity per se (MYC_targets_V1/V2), was solely driven by the luminal cells (Fig.3a, b). In fact, the near totality of the MYC-driven transcriptional...
Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest indicators of aggressive and chemotherapy-refractory disease in children with neuroblastoma, the most common extracranial ...
Myc oncoproteins are overexpressed in most cancers and are sufficient to accelerate cell proliferation and provoke transformation. However, in normal cells Myc also triggers apoptosis. All of the effects of Myc require its function as a transcription factor that dimerizes with Max. This complex induce...
Several targets have been identified by the activation/repression of MYC. Deregulated expression levels of lncRNAs have also been observed in many cancers.#The aim of the present study is to investigate the lncRNA profiles which depend on MYC expression levels in SCLC.#Firstly, we constructed ...