SignalSig Transduct Target Ther, 2020, 5(1): 13. [21]Katono K, Sato Y, Jiang SX, et al. Prognostic significance of MYH9 expression in resected non-small cell lung cancer[J]. PLoS One, 2015, 10(3): e0121460. [22]Chen M, Sun LX, Yu L, et al. MYH9 is crucial for stem ...
Target. Ther. 7, 1–21 (2022). Google Scholar Hubbard, G. K. et al. Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer. Cancer Res. 76, 283–292 (2016). Article CAS PubMed Google Scholar Tomlins, S. A. et al....
mutually exclusive expression (i.e. negative covariance) between two genes at a single cell level.gCovariance analysis in the luminal subset reveals a shift from canonical AR target genes in the transcripts co-expressed withArupon MYC overexpression (VP;n = 1 per genotype). NES: normalized...
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis Yiwu Yan, Bo Zhou, Chen Qian, Alex Vasquez, Mohini Kamra, Avradip Chatterjee, Yeon-Joo Lee, Xiaopu Yuan, Leigh Ellis, Dolores Di Vizio, Edwin M. Posadas,...
The GSEAanalysis revealed that the high ARHGEF expression was significantly associated with "HALLMARK-MYC-TARGET-V2" geneset (p=0.04). Also high ARHGEF expression was significantly associated with CDC25A (p=0.006) which is the downstream gene of c-MYC pathway and regulates cell cycle, ...
1F). To further validate the findings and address potential off-target effects of the sgRNAs, we also performed KLF16 knockdown (KD) using shRNA in these cell lines (Supplementary Fig. S1C). Both KO and KD of KLF16 impaired colony formation, cell proliferation, and tumor growth in BLCA ...
we have identified and validated EPIC1 as an oncogenic lncRNA by interacting with the MYC protein and promoting cell-cycle progression. These discoveries expand upon the known mechanisms of MYC activation in cancer and pave ...
A chimeric protein containing the N terminus of the adeno-associated virus rep protein recognizes its target site in an In vivo assay. Authors:Cathomen T, Collete D, Weitzman MD Journal:J Virol PubMed ID:10666268 'The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are ...
(which eventually leads to overexpression ofERG) was shown to be correlated toMYCexpression87andDLX1is a known transcriptional target of ERG76,88,89(Fig.6a). To assess an independent association of the transcriptomic markers to Enzalutamide resistance (independent of MYC and NME2), we performed ...
We assumed the surrounding cell population was the sender cells (Gata6lin− cells) and those in the wound area (Gata6lin+ cells) were the target cells. First, we defined the genes expressed in both populations. Next, we selected the genes that were expressed (that is, receptors) in ...