In addition, the difference in tumor immune function among the low- and high-risk populations was compared by single sample gene enrichment analysis. Immunotherapy and prediction of response to the anticancer drug have shown that the risk signature of the MYC target gene s...
target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG...
causing about 100,000 US cancer deaths per year. Therefore, disruption of MYC function has recently been identified as an important target for anti-cancer drug development. Analyzing the expression of MYC-responsive genes can help researchers to better understand its normal functions, its role in ...
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large body of evidence indicates that MYC proteins are transcription factors, studying their function has focused on the biology of their target genes. Detailed studies of M
One of the Myc target genes might be specifically involved in cell proliferation, differentiation, or both. Thus, studies of each Myc target gene on proliferation and differentiation will help elucidate the problems, and it is a next, important issue to determine whethermina53 is involved in ...
Target gene-independent functions of MYC oncoproteins. Nat. Rev. Mol. Cell Biol. 21, 255–267 (2020). Article CAS PubMed PubMed Central Google Scholar Wolf, E., Lin, C. Y., Eilers, M. & Levens, D. L. Taming of the beast: shaping Myc-dependent amplification. Trends Cell Biol. ...
5H). Collectively, these results indicate that KLF16 and MYC colocalize on chromatin, and that KLF16 promotes MYC binding to the promoters of target genes. Fig. 5 KLF16 and MYC colocalize on chromatin, and KLF16 facilitates MYC binding to target gene promoters. A Endogenous KLF16 was ...
and its overexpression drives the formation of what is estimated to be 20% of all human cancers, causing about 100,000 US cancer deaths per year. Therefore, disruption of MYC function has recently been identified as an important target for anti-cancer drug development. Analyzing the expression ...
identified MYC target genes that might explain this requirement by using expression profiling. Among the targets they identified were genes encoding enzymes that regulate several rate-limiting steps in nucleotide biosynthesis. At least three of these enzymes, thymidylate synthase (TS), inosine ...
MYC, a major oncogenic transcription factor, regulates target genes involved in various pathways such as cell proliferation, metabolism and immune evasion, playing a critical role in the tumor initiation and development in multiple types of cancer. In liver cancer, MYC and its signaling pathways unde...