specificity: \(z_i\, = \,\frac{{expr_i\, - \,mean(Expr)}}{{sd(Expr)}}\), where \(expr_i\) is the average gene expression of the gene in the ith tissue, Expr represents the collection of its average gene expression in all tissues, and \(sd\) is the standard deviation of ...
Pretreatment with sgDNase enriches all mutant strands with initial frequencies down to 0.01% and leads to high discrimination factors for all types of single-nucleotide mismatch in multiple sequence contexts, as we show for the identification of low-abundance mutations in samples of blood or tissue ...
The mutation is the engine of evolution that generates genetic diversity. It has been demonstrated that mutations in the SARS-CoV-2 genome are responsible for a drastic change in the protein structure and lead to an increase in the infectivity, fitness, and virulence of SARS-CoV-2 [19]. 10...
Even the proliferation of a subclone in cell culture and in mouse subcutaneous graft altered the types and frequencies of targeted TSG mutations in the absence of continuing CRISPR/Cas9 genome editing, indicating a new source outside primary chromosomes for the development of IGH in these liver ...
Bennett discovered genealogy at age 12 and, like many genealogists, created a pedigree chart by talking to his family. I love the mark-outs. How many of us still have our first chart with its edits? This is the young Bennett Greenspan, whose interest in genealogy would one day unlock secr...
Experiments indicate that DeepGene outperforms three widely adopted existing classifiers, which is mainly attributed to its deep learning module that is able to extract the high level features between combinatorial somatic point mutations and cancer types. 展开 ...
2001), and its expression is seen in the epithelial-derived ameloblasts synthesizing and secreting enamel matrix proteins (Fried et al. 1996). A BLASTn search of the NCBI human est database, using the GJA1 mRNA sequence NM_000165, revealed GJA1 expression in libraries derived from placenta,...
The genotype of the loci in NL895 and its female parent (I69) was different from that of its male parent (I45). Conclusions This research provides resources for further chloroplast genomic studies of a F1 full-sibling family derived from a cross between I69 and I45, and will improve the ...
Moreover, no studies to date have determined the functional landscape of 5′-UTR mutations across cancer progression at both the transcript and translation levels simultaneously. Thus, current approaches lack the ability to mine the breadth of full-length 5′-UTR activity and the depth of its ...
and treatment of COVID-19 has improved4,5,6. SARS-CoV-2, the new member of the Coronaviridae family (Betacoronavirus), has improved its ability to survive and preserve its generation5. Compared to other Coronaviridae members, higher virulence besides significant pathogenicity may justify this un...