Differences were found for the mutational profiles endogenous gene and transgene with respect to the location of the mutations and the orientation of basepair substitutions in the DNA strands. In most cases, these differences could be explained by the nature of the target genes. The results ...
The “guardian of the genome”TP53is the most frequently mutated gene in malignant tumors [1,2]. WhileTP53mutations can be found in most cancer types, their prevalence varies strongly between different entities [3,4]. The vast majority ofTP53mutations are located in the DNA-binding domain (DB...
Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans. Infect. Immun. 70, 4955–4960 (2002). Article CAS PubMed PubMed Central Google Scholar Wengenack, N. L., Todorovic, S., Yu, L. & Rusnak, F. Evidence for differential ...
studies, especially in the light of new information onthetypes of germ-cellDNA mutations involved (largely DNA losses) and [...] daccess-ods.un.org daccess-ods.un.org 委员会审议并分析了这些研究中的变异数据,尤 其是考虑到相关生殖细胞 DNA 变异类型(在很大程度上是 DNA 丢失)的新信 ...
Replication process: Transferring the genetic information from one cell to its daughters and from one generation to the next and equal distribution of DNA during the cell division Mutations: The changes which occur in the DNA sequences Transcription ...
Comparison of somatic mutations and CNV Comparison of the somatic mutations and gistic-identified CNVs between high- and low-invasiveness score groups across cancer types was tested using the Kruskal–Wallis test, where p-values < 0.01 after adjustment for mutational frequency were considered stati...
"Pinot Grigio (aka Pinot Gris) ,a gray-red grape, is one of the many mutations of Pinot (Pinot Noir, Pinot Blanc, etc). It produces a light-bodied, dry, refreshing wine with a citrus character and zesty acidity. Typical flavors include lemon, lime, pear, and green apple. It's a ...
Cancers arise from genetic mutations which enable cancer cells to grow, divide, migrate and avoid programmed death (apoptosis) that normal cells undergo when damaged or no longer needed. Cancers grow into malignantmasses of tissue known as tumors, lesions or nodules and can spread to other parts...
Centromere alterations and breaks have also been found in human genetic diseases like the Immunodeficiency, Centromeric region instability, Facial anomalies syndrome (ICF), where mutations of DNA Methyl-Transferase 3 Beta (DNMT3B) (55% of reported cases), ZBTB24, CDCA7, or HELLS44,45 correlate ...
An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat. Methods 6, 917–922 (2009). Article CAS PubMed Google Scholar Watanabe, Y. et al. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS ONE 6, e23320 (...