Track 1, Passive Muscle Relaxation, offers well-structured guidance for relaxing major muscles. Track 2, Self-Generated Relaxation, allows more flexible practice in body scanning for residual stress and discovering one's own formula for relief. Also available on audiocassette.Mark S. Schwartz...
For relaxation, Ca2 þ is actively removed from the cytosol into the sarcoplasmic reticulum by Serca proteins, which are ATP-dependent Ca2 þ -specific ion pumps5,6. All MRF proteins bind to E-box sequences that are present in the enhancers or promoters of genes coding for most muscle ...
This includes significant expression changes in skeletal mus- cle proteins that are involved in ion homoeostasis, cellular signalling cascades, the regulation of excitation–contrac- tion coupling, the sarcomeric units and the maintenance of contraction-relaxation cycles, the formation of the extracel- ...
Aortic rings (Z12 tissues for each condition) were contracted with 108 mM KCl for two contraction/relaxation cycles or until reproducible forces were obtained. Isometric force was normalized to tissue cross-sectional area. Arterial responses were measured in response to both depolarization (KCl ...
In genome-wide expression profiling, we found that >70% of genes selectively induced by cyclic stretch-relaxation of SMC in vitro were similarly up-regulated by PDGF treatment [26]. In that study, informatics analysis revealed AP-1 as the transcription factor most significantly associated with ...
The sarcoplasmic reticulum Ca2+-ATPase is a pump that transports calcium ions from the cytoplasm into the SR, bringing about relaxation of a contracting muscle [22]. Myosin light chain kinase regulates contraction in many muscles by phosphorylating the myosin regulatory light chain, a process that ...
Repetitive stretch/relaxation of the differentiated skeletal muscle cells stimulated the acute release of IGF-1 during the first 4 h after initiating mechanical activity, but caused no increase in the long-term secretion over 24-72 h of IGF-1, or its binding proteins. Varying the intensity and...
due to relaxation of imprinting in muscle cells. To address this issue, polymorphic fibroblasts expressing exogenous MyoD were analyzed for the relative amounts of maternal and paternal Kcnq1ot1 transcripts, by allele-specific RT-qPCR. As reported in Fig.4,Kcnq1ot1expression is restricted exclusive...
Consistent with the absence of a rapid relaxation effect, we were unable to detect an increase in intracellular cAMP in ASM cells from acetate or propionate exposures of 30 min and 4 h (data not shown) using a sensitive immunofluorescence assay which we have previously utilized for isolated...
A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demonstrate that besides a dominant role in controlling cellular metabolism...