Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular change...
Tumour invading muscle in head and neck squamous cell carcinoma (HNSCC) is often associated with destructive growth and poor prognosis. However, the phenotypic functions and pathological mechanisms of muscle-invasive cancer cells in tumour progress remai
Sitting: Sit upright in a firm seat and straight-backed chair, knees slightly apart, feet flat on the floor or legs stretched out in front and crossed at the ankles. • Standing: Stand by a chair, knees slightly bent with feet a shoulder-width apart and toes slightly pointed outward. ...
Fig. 1: The population dynamics of MuSCs and niche cells are altered in aging.a Schematic diagram of the workflow for the isolation and single-cell RNA sequencing of young and aged MuSCs, macrophages and Fibro-Adipogenic Progenitors (FAPs).b...
eye, they first encounter thecornea, a translucent, bulging domed section of the sclera at the front of the eyeball, kept moist and nourished by tears. The cornea provides all the refraction needed to focus on an object more than about 6m (20ft) away (if the eye is young and healthy)...
Extracellular vesicles (EVs) play an important role in human and bovine milk composition. According to excellent published studies, it also exerts various functions in the gut, bone, or immune system. However, the effects of milk-derived EVs on skeletal
Flexor hallucis longus muscle with human leg and foot bones outline diagram. Labeled educational physiology scheme with feet phalanges and metatarsal skeletal and muscular system vector illustration.,站酷海洛,一站式正版视觉内容平台,站酷旗下品牌.授权内容
Background Cancer cachexia is a wasting disorder characterized by significant weight loss, and is attributed to skeletal muscle weakness. In the process of cancer development, microRNAs act as oncogenes or tumor suppressors. Moreover, they are implicated in muscle development and wasting. This study...
For visualization purposes, clusters are labeled with the most informative term; node size represents the term enrichment significance and nodes. Full size image We further investigated the effects of exercise training in slow- and fast-twitch muscle fibers individually. We observed greater adaptation ...
However, with the advent of mapping methods and assays for early muscle-specific gene expression patterns, separate and distinct sites of origin for all eye muscles within pre-otic (i.e., located rostral, in front of the developing inner ear) paraxial mesoderm was confirmed (Figure 1). Sign...