then the Karam and Leblond model (all cells rapidly arise from a long-lived, self-renewing, multipotent stem cell) would result in temporary labeling of the pit lineage with eventual loss of the label because the stem cell would not be labeled, and pit cell progenitors are not long-lived....
All muscle fibers can produce energy both anaerobically (i.e., without oxygen, labeled as glycolytic) and aerobically (i.e., with oxygen, labeled as oxidative). Despite the ability of all muscle fibers to produce energy by both glycolytic and oxidative processes, one or the other may ...
If the most abundant cell type contributed less than 70% of cells, the neighborhood was labeled as mixed and filtered out. Additionally, if the neighborhood contained more than 90% of cells from one donor, it was labeled as ‘Donor-specific’ and was filtered out.Aging differential gene ...
Background Tumour invading muscle in head and neck squamous cell carcinoma (HNSCC) is often associated with destructive growth and poor prognosis. However, the phenotypic functions and pathological mechanisms of muscle-invasive cancer cells in tumour progress remains unknown. In this study, we aimed ...
To cluster cells, we used UMAP78 followed by the Walktrap community finding algorithm79 to reduce the dimensionality of the data and pull together similar cell populations into separated clusters which can then be labeled. To annotate the main clusters, we used the expression of Adgre1, Ptprc,...
Effect of urolithin A vs placebo supplementation on muscle endurance and mitochondrial health in older adults View LargeDownload Figure 1. CONSORT Diagram of Participant Flow Through the Study View LargeDownload Figure 2. Effect of Urolithin A Supplementation on the 6-Minute Walk Distance and ...
BME or HME was labeled with a 1:1000 working solution of DiI, and cell membranes were labeled using a 1:1000 working solution of DiO, and cell nuclei were labeled using a 10 µg/mL Hoechst 33,342 working solution, respectively. Excess fluorescent dyes were washed away after incubating at...
A normal ECG tracing is presented in Figure 7. Each component, segment, and interval is labeled and corresponds to important electrical events, demonstrating the relationship between these events and contraction in the heart. There are five prominent points on the ECG: the P wave, the QRS comple...
For visualization purposes, clusters are labeled with the most informative term; node size represents the term enrichment significance and nodes. Full size image We further investigated the effects of exercise training in slow- and fast-twitch muscle fibers individually. We observed greater adaptation ...
The free energy of binding of ATP to the myosin changes the conformation of its actin binding site in such a way that the affinity for actin is drastically reduced. At rest, most myosin heads will be in the M-ADP-Pistate, ready to enter stage 3 in this diagram when circumstances allow...