A skeletal muscle fiber is formed from the fusion of many embryonic cells during development to form slender cells that extend from one end of the muscle to the other. Each muscle fiber normally has one nerve fiber that extends to the cell membrane, forming the neuromuscular junction. There is...
neighboring muscle cells; inTbx5mutants MCT fibroblasts express less and more disorganized N-Cadherin and β-Catenin (Hasson et al., 2010) andOSR1regulates a large number of secreted signals (e.g., SDF and Bmp4) andextracellular matrix proteins(e.g., Col6;Vallecillo-García et al., 2017...
However, bringing cell cultures into the classroom is challenging for biology teachers since culturing cells requires sophisticated and expensive instruments such as a CO2incubator and an inverted phase-contrast microscope. Here, we describe easy and affordable methods to culture and observe skeletal ...
Thus, it can be concluded that local restrictions of diffusion of metabolites in a cell are a system-level properties caused by complex structural organization of the cells, macromolecular crowding, cytoskeletal networks and organization of metabolic pathways into multienzyme complexes and metabolons. ...
Joseph A. Baur Nature Reviews Molecular Cell Biology(2024) Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T Julian Mevenkamp Yvonne M. H. Bruls Vera B. Schrauwen-Hinderling Nature Communications(2024) ...
Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples that muscle stem
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy. Myosatellite cells, also known as skeletal muscle stem cells (MuSCs), pl
With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and pro...
Skeletal muscle conveys several of the health-promoting effects of exercise; yet the underlying mechanisms are not fully elucidated. Studying skeletal muscle is challenging due to its different fiber types and the presence of non-muscle cells. This can b
primary cells retain many of the important physiological properties of their origin tissue systems and closely mimic the in vivo conditions. They, therefore, offer ideal cell models for a vast variety of research, from fundamental cell biology and physiology, developmental biology, disease mechanisms,...