Fig. 4: Development of an allogeneic stem cell transplantation model to directly quantify the effect of the niche environment on the transcriptome of MuSCs. a Schematic diagram of the pipeline for allogeneic MuSC transplantation. b Immunofluorescent staining for PAX7, Laminin and DAPI on cross-sectio...
Tumour invading muscle in head and neck squamous cell carcinoma (HNSCC) is often associated with destructive growth and poor prognosis. However, the phenotypic functions and pathological mechanisms of muscle-invasive cancer cells in tumour progress remai
Key proteins involved in structural maintenance of the extracellular matrix-sarcolemma axis via cell–matrix adhe- sion processes and the provision of mechanical support and lateral force transmission include various (i) collagen iso- forms (Col I, III, IV, V and VI), (ii) a large number of...
Aging Cell. 2019;18(1):e12861. doi:10.1111/acel.12861PubMedGoogle Scholar 2. Fulmer T, Reuben DB, Auerbach J, Fick DM, Galambos C, Johnson KS. Actualizing better health and health care for older adults. Health Aff (Millwood). 2021;40(2):219-225. ...
Several gene and cell-therapy studies have been performed on satellite cells, the primary skeletal muscle stem cells involved in muscle regeneration. However, these have mainly been based on artificial replacement or augmentation of the missing protein. Satellite cells are a particularly appealing ...
SRPK3encodes a protein kinase member of the SRPK family that phosphorylates proteins containing serine-arginine dipeptide motifs (SR proteins)13. In humans, three tissue-specific SRPKs have been described14,15, with SRPK3 being expressed predominantly in striated muscle16. SRPKs primarily regulate ...
Lewis lung carcinoma (LLC) cell line was used to establish a cachexia model to explore the functions of miR-29c and LIF in lung cancer cachexia. Furthermore, in vitro (in C2C12 myotubes) and in vivo (in LLC tumor-bearing mice) experiments were performed to explore the mechanisms of miR-...
30.Steinert ND, Potts GK, Wilson GM, Klamen AM, Lin KH, Hermanson JB, McNally RM, Coon JJ, Hornberger TA. Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function. Cell Rep. 2021; 34:108796.] ...
FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus Dev. Cell, 32 (2015), pp. 707-718 View PDFView articleView in ScopusGoogle Scholar Wang et al., 2004 Z. Wang, D.Z. Wang, D. Hockemeyer, J. McAnally, A. Nordheim, E.N. Olson Myocardin and ternary comp...
In agreement with these changes, integration analysis of differentially expressed genes and proteins in visceral SMC exposed to PDGF identified (i) regulation of cell proliferation; (ii) negative regulation of cell death; and (iii) regulation of cell motion as 3 of the most over-represented ...