Muscle Atrophy Skeletalmuscle atrophyis known to occur in response to disuse and numerous chronic conditions, such as cancer, AIDS, and senilesarcopenia(the age-related loss of muscle mass). Here we will focus on the mechanisms underlying sarcopenia, which is the major cause ofmuscle weaknessin ...
Related to Fig. 7. a, Gastroconemius complex skeletal muscle mRNA expression of transcripts of atrophy related genes Trim63 (aka Murf1), Fbxo32 (aka MAFbx or Atrogin-1), Ddit4 (aka Redd1), Klf15 and Foxo3a from lean C57Bl/6J (Bl6) and age-matched obese/diabetic BKS-db/db mice ...
The fact that two different FoxO1,3,4 knockout mice resulted in comparable biological effects strongly supports the conclusion that the FoxO family is a master regulator of the atrophy programme under low nutrient conditions. FoxOs directly regulate atrophy-related genes. To determine whether the ...
Muscle atrophy usually leads to the loss of muscle mass and function and is characterized by a reduction in muscle fiber size and mass, a conversion of muscle fiber type and an imbalance between protein synthesis and degradation in the muscle [6]. Under pathological conditions, skeletal muscle ...
Cancer-induced muscle atrophy mainly occurs due to high levels of circulating humoral and tumoral signaling factors. Specifically, cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), and TNF-related weak inducer of apoptosis (TWEAK) have been ...
Muscle atrophy is characterized by decreased muscle mass, function, and strength. Synthetic glucocorticoids, including dexamethasone (Dexa), are commonly used to treat autoimmune diseases. However, prolonged exposure of Dexa with high dose exerts severe
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the muscle mass reduction seen in sarcopenia and the decline in neuronal function characteristic of neurode...
[7]. FoxO1 is a forkhead-type transcription factor and activates the expression of atrophy-related genes, such asatrogin-1andcathepsin L, in various muscle atrophy-related conditions [15,16]. Mt1 is a protein, belonging to the metallothionein family of proteins, that regulates the homeostasis ...
What is the difference between sarcopenia and muscular atrophy? Muscular atrophy means loss of muscle mass. When you have age-related sarcopenia, you have muscular atrophy. But muscular atrophy isn't always sarcopenia because it can have causes other than aging. For example, someone on bed rest...
Skeletal muscle undergoes atrophy and loss of force during long space missions, when astronauts are persistently exposed to altered gravity and increased ionizing radiation. We previously carried out mass spectrometry-based proteomics from skeletal muscl