Pharmacodynamic Properties Muromonab CD3 (OKT3), a murine monoclonal antibody directed against the CD3 antigen (linked to the T cell antigen receptor; TCR) on mature peripheral human T cells, effectively blocks all T cell function. The mechanism of action includes antigenic modulation of the CD3/...
在1986年,Muromonab-CD3 ( 商品名: Orthoclone OKT3 )是第一种被批准用作人类治疗药物的单克隆抗体(mAb)。 这种针对T淋巴细胞CD3复合物的鼠抗体已被广泛用于预防器官移植患者的急性排斥反应。 药品中文名称:鼠源CD3单克隆抗体 药品英文名称 Muromonab CD3 药品中文商品名 爱欧山 药品英文商品名 iort3 但是来源于鼠...
Muromonab CD3 (Orthoclone OKT3, Orthoclone, OKT3) is the first monoclonal antibody to become available for therapy in humans. In effect it blocks all cytotoxic T cell function. Clinical trials show that muromonab CD3 is effective in reversing acute renal, hepatic, cardiac and combined kidney- panc...
OKT3, CAS: 140608-64-6 Note For research use only. Not suitable for clinical or therapeutic use. 关键字:Muromonab;莫罗单抗;140608-64-6;T3E;CD3e; 公司简介 武汉佰乐博生物(Biolab Reagents)由五位毕业于华中科技大学,华中农业大学,武汉大学等知名高校,且具有二十年工作经验的生命科学领域顶级研究者创立...
Muromonab-CD3 (trade name Orthoclone OKT3, marketed by Janssen-Cilag) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first ...
药品名称:ORTHOCLONE OKT3,活性成分:MUROMONAB-CD3,剂型:VIAL,规格:1MG/ML,药品注册申请号:103463,产品号:001
Muromonab-CD3 (murine, Orthoclone-OKT3) is an unmodified mouse immunoglobulin, an IgG2a, monoclonal. It binds a glycoprotein on the surface of mature T lymphocytes. Mature T cells have, as part of the signal transduction machinery of the T-cell receptor complex, a set of three glycoproteins th...
Summary The marketing approval of muromonab–CD3 (Orthoclone OKT3®;) in 1986 is a widely recognized landmark in the field of antibody therapeutics development. The product provided benefit to solid organ transplant patients experiencing acute rejection, but subsequent advances in transplant medicine le...
别名:OKT3 纯度:>97% 规格:2 mg/mL 产地:国产 Muromonab—CD3优势介绍: 1、几千余种植物标准品/对照品现货供应。 2、学校及科研单位,支持货到付款。 3、产品需求量大,可定制大包装。 4、进口多个品牌同时代理,如:Dr.E,TRC、USP、EP、美国中草药、sigma等品牌。
Sgro C.Side-effects of a monoclonal antibody,muromonab CD3/orthoclone OKT3:bibliographic review.Toxicology. 1995Side- effects of a monoclonal antibody, mu-... C Sgro - 《Toxicology》 被引量: 201发表: 1995年 Muromonab CD3 Synopsis The murine monoclonal antibody muromonab CD3 (0KT3) is directed ...