Synopsis Muromonab CD3 (Orthoclone OKT3, Orthoclone, OKT3) is the first monoclonal antibody to become available for therapy in humans. In effect it blocks all cytotoxic T cell function. Clinical trials show that muromonab CD3 is effective in reversing acute renal, hepatic, cardiac and combined ...
一、Muromonab-CD3 在1986年,Muromonab-CD3 ( 商品名: Orthoclone OKT3 )是第一种被批准用作人类治疗药物的单克隆抗体(mAb)。 这种针对T淋巴细胞CD3复合物的鼠抗体已被广泛用于预防器官移植患者的急性排斥反应。 药品中文名称:鼠源CD3单克隆抗体 药品英文名称 Muromonab CD3 药品中文商品名 爱欧山 药品英文商品名 ...
OKT3, CAS: 140608-64-6 Note For research use only. Not suitable for clinical or therapeutic use. 关键字:Muromonab;莫罗单抗;140608-64-6;T3E;CD3e; 公司简介 武汉佰乐博生物(Biolab Reagents)由五位毕业于华中科技大学,华中农业大学,武汉大学等知名高校,且具有二十年工作经验的生命科学领域顶级研究者创立...
药品名称:ORTHOCLONE OKT3,活性成分:MUROMONAB-CD3,剂型:VIAL,规格:1MG/ML,药品注册申请号:103463,产品号:001
产品名称:Muromonab—CD3 产品编号:MA1029 C A S 号: 别名:OKT3 纯度:>97% 规格:2 mg/mL 产地:国产 Muromonab—CD3优势介绍: 1、几千余种植物标准品/对照品现货供应。 2、学校及科研单位,支持货到付款。 3、产品需求量大,可定制大包装。 4、进口多个品牌同时代理,如:Dr.E,TRC、USP、EP、美国中草药、...
Muromonab-CD3 (trade name Orthoclone OKT3, marketed by Janssen-Cilag) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first ...
靶点:OKT3 免疫原:Human 宿主:是 用途:仅用于科研 保质期:1 year 应用范围:类似物,阳性对照抗体 产地:France 标记物:Unconjugate 品牌:AntibodySystem 包装规格:100ug 抗原来源:Mammalian cells 适应物种:Human 克隆性:是 标识物:Unconjugate 形态:Liquid ...
Summary:We retrospectively evaluated response to monoclonal antibody directed against CD3 (OKT3) treatment in 43 patients with steroid-resistant acute graft-versus-host disease (aGvHD) following allogeneic hematopoietic cell transplantation. Median duration of OKT3 therapy was 9 (range, 1–20) days. In...
Muromonab与T细胞表面糖蛋白CD3ε链结合。它通过诱导Fc介导的细胞凋亡、抗体介导的细胞毒性和补体依赖性细胞毒性来杀伤CD3阳性细胞。 给药方式 IV 推荐剂量 单次静脉注射5mg/天,每次不超过1分钟,持续10至14天 药代动力学 半衰期短,体外试验显示为0.8小时 临床试验 在一项随机、对照的临床试验中,Orthoclone OKT3与常规...
Pharmacodynamic Properties Muromonab CD3 (OKT3), a murine monoclonal antibody directed against the CD3 antigen (linked to the T cell antigen receptor; TCR) on mature peripheral human T cells, effectively blocks all T cell function. The mechanism of action includes antigenic modulation of the CD3/...