Mural Cell(血管壁细胞)是周细胞和血管平滑肌细胞的统称,主要负责维持血管稳定性和功能,参与血管生成、疾病发展及修复过程。以下从定
Mural cell coverage is unusually high in the CNS, likely owing to its role in the BBB and the unique blood flow requirements of the adult CNS. During development, mural cells can regulate vessel growth and maturation via the release of a variety of growth factors (bFGF, VEGF, TGFβ) as ...
NicheNet analysis on the single cell transcriptomic data revealed little signalling from the ECs to the mural cells; instead, mural cells signalled strongly to ECs. Mechanistically, pericyte dysfunction induces an EC growth arrest via TNF伪-dependent paracrine signalling and downstream signalling through ...
The cells are typically maintained in a humidified incubator at 37°C with 5% CO2. The culture medium should be changed every 2-3 days to remove waste products and provide fresh nutrients. Monitoring of pH and osmolality is also important to ensure optimal conditions for cell growth....
At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in patho
英汉 网络释义 un. 1. 壁细胞
Interestingly, endothelial [22] or mural [23] cell-specific laminin-α5 knockout mice fail to show increased neurovascular permeability or other abnormalities under homeostatic conditions, highlighting a dispensable role of endothelial or mural cell-derived laminin-α5. Considering potential functional ...
Several key signaling pathways coordinate mural cell/endothelial cell interactions during development, including TGF-β, angiopoietins, sphingosine-1-phosphate, Notch, and platelet-derived growth factor B (PDGF-B) (Armulik et al., 2005). Sprouting endothelial tubes secrete PDGF-B, which signals thro...
文章题目:Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies 翻译为:单细胞分析鉴定表达CD19的脑mural细胞为CAR-T免疫疗法的潜在非肿瘤靶标 期刊:《Cell》,2020年10月,IF=38.6
Many important cell types in adult vertebrates have a mesenchymal origin, including fibroblasts and vascular mural cells. Although their biological importance is undisputed, the level of mesenchymal cell heterogeneity within and between organs, while appreciated, has not been analyzed in detail. Here, ...