26,78] and examined laminin-α5 expression in these cells. Isolated cells expressed mural cell marker SMA (Fig.1c), suggesting they were indeed mural cells. Immunocytochemistry revealed laminin-α5 expression in control but not α5-PKO mural cells (Fig.1c). Quantification...
This study aims to characterise the distribution of cells that express the mural cell marker PDGFRβ in the mouse pituitary and establish whether these cells are folliculostellate. By immunohistochemical localisation we determine that approximately 80% of PDGFRβ+ cells in the mouse pituitary have a...
3). With marker-based annotations22, 11 major cell types were identified, including macrophages (Macro), T cells, mural cells, neutrophils (Neutro), monocytes, ECs, astrocytes/oligodendrocytes (Astro/Oligo), endothelial-to-mesenchymal transition (EndMT) cells, fibroblasts, B cells and dividing ...
1f). The short-list of common fibroblast markers included many ECM genes, such as Col1a1, Col1a2, Col5a1, Loxl1, Lum, Fbln1, and Fbln2, as well as the cell surface receptors Cd34 and Pdgfra. Importantly, this list did not contain the often-used marker fibroblast-specific protein-1 ...
Considering potential functional redundancy, we hypothesize that endothelial and mural cell-derived laminin-α5 may be able to compensate for each other’s loss. To test this hypothesis and investigate the functional significance of laminin-α5 in neurovascular integrity, we further generated compound ...
These data were in line with the findings obtained by data mining in the TCGA data set: significant positive correlations were identified between PECAM1 (endothelial cell marker), Endoglin (endothelial (progenitor) cell marker) and CECR1 expression in a set of 166 samples (Figures 1d and f)....
Vascular mural cells (vMCs) play an essential role in the development and maturation of the vasculature by promoting vessel stabilization through their interactions with endothelial cells. Whether endothelial metabolism influences mural cell recruitment
The antineoplastic agent paclitaxel (TaxolTM), a microtubule stabilizing agent, is known to arrest cells at the G2/M phase of the cell cycle and induce apoptosis. We and others have recently demonstrated that paclitaxel also activates the c-Jun N-terminal kinase/stress-activated protein kinase ...
A seemingly vascular BM-embedded cell might be sandwiched between neighboring vascular and non-vascular BMs. This may be the case for cells located within the Virshow-Robin space. For practical reasons, current PC identification therefore relies on a combination of morphological criteria and marker ...
A seemingly vascular BM-embedded cell might be sandwiched between neighboring vascular and non-vascular BMs. This may be the case for cells located within the Virshow-Robin space. For practical reasons, current PC identification therefore relies on a combination of morphological criteria and marker ...