In oncology, technologies for clinical molecular imaging are used to diagnose patients, establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed methods increase the number of disease-specific biomarkers that can be detected simultaneously, such as the overexpression of oncog...
Multiplexed imaging in oncology Article 27 May 2022 Radiogenomics: a key component of precision cancer medicine Article 06 July 2023 Multiparametric MRI for characterization of the tumour microenvironment Article 19 April 2024 References NIH Research: A Q&A with Harold Varmus, M.D., Director,...
SignalStar ™ Multiplex IHC labels up to eight targets in FFPE tissues simultaneously. Briefly, oligo-conjugated antibodies are added in a cocktail to the sample, then complementary oligos with fluorescent dyes are used to amplify the signal of up to four antibodies in the first imaging round. ...
Medical imaging technologies have undergone explosive growth over the past few decades and now play a central role in clinical oncology. Targeted magnetic resonance imaging (MRI) has emerged as a promising diagnostic approach offering high resolution depictions of pathological anatomy and the detection o...
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation (TYPE
(EPINUC), DNA methylation and cancer-specific protein biomarkers. Our system allows for high-resolution detection of six active and repressive histone modifications and their ratios and combinatorial patterns on millions of individual nucleosomes by single-molecule imaging. In addition, our system ...
27 The use of automated and quantitative imaging is a step toward improving this, by removing interobserver and intraobserver variability.12 In this study, we demonstrate that it is feasible to estimate the percentage positivity for the TFH markers, BCL6 and PD1, in AITL tumor cells. The ...
Tumor growth was monitored by in vivo imaging (IVIS) of the luciferase signal from SK-BR-3 cancer cells in each mouse over the course of 41 days. RR zipCAR with α-Her2-EE zipFv showed robust tumor burden clearance, comparable to the conventional Her2 CAR. However, T cells expressing ...
Individual risk factors, imaging characteristics, biomarkers, and prediction models are currently used to assist in risk stratifying patients, but such ... R Paez,MN Kammer,P Massion - 《Current Opinion in Pulmonary Medicine》 被引量: 0发表: 2021年 Factors That Influence Physician Decision Making...
Quantitative multiplexed imaging technologies for single-cell analysis to assess predictive markers for immunotherapy in thoracic immuno-oncology: promises and challengesTUMOR MUTATIONAL BURDENTYRAMIDE SIGNAL AMPLIFICATIONARTIFICIAL-INTELLIGENCECANCERIMMUNOHISTOCHEMISTRY...