Multiple system atrophy : Prognosis and treatment Section EditorFactor, Stewart AEsper, Christine DossHurtig, Howard IDashe, John F
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Multiple System Atrophy (MSA) and Parkinson's diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of the protein α-synuclein characterize them. A plethora of evidence indicates the involvement of these rogue inclusions in a cascade of events that disturb ...
These approaches have included the use of magnetic resonance imaging (MRI) measures such as gadolinium enhancement, new T2 lesions, the volume of T2 lesion burden, brain atrophy (either whole brain or separately for grey and white matter), spinal cord atrophy, cortical connectivity, and ...
Multiple sclerosis is twice as common in women as in men; men have a tendency for later disease onset with a poorer prognosis. The incidence of MS is low in childhood, increases rapidly after the age of 18, reaches a peak between 25 and 35, and then slowly declines, becoming rare at ...
Conclusions Magnetic resonance imaging has become a powerful tool for the study of MS, with practical applications in diagnosis and prediction of prognosis and with research applications in the study of MS natural history. In addition, MRI is now included as an adjunctive measure in clinical trials...
The lesion-led subtypes had the worst prognosis in terms of accumulation of pathology (faster lesion accumulation) and disability progression. Disease duration, both in the training dataset (9.09 years) and the validation dataset (11.63 years), was the highest in the lesion-led subtype. We postul...
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. Nat. Commun. 10, 2236 (2019). Google Scholar Gresle, M. M. et al. Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells. Life Sci. ...