Increasing evidence supports a link between multiple system atrophy and coenzyme Q 10 (CoQ 10 ) biosynthesis. However, so far this knowledge was not translated into tangible benefits for affected patients. Poor bioavailability of oral CoQ 10 might constitute a major problem. Current research suggests...
Monzio Compagnoni and Di Fonzo Acta Neuropathologica Communications (2019) 7:113 https://doi.org/10.1186/s40478-019-0730-6 REVIEW Open Access Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives Giacomo Monzio Compagnoni and Alessio Di Fonzo* ...
Sleep disorders in multiple system atrophy (MSA) are common manifestation and include reduced and fragmented sleep, excessive daytime sleepiness, REM sleep
Radford, R. et al. The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to alpha-synuclein inclusions., 68–81 (2015). Valdinocci, D., et al. Extracellular interactions of alpha-synuclein in multiple system atrophy., 4129 (2018). Croisier, ...
Multiple sclerosis (MS) is a chronic, complex, and often disabling disease of the central nervous system (CNS) with a variable clinical course. There are two basic ...
These findings have implications for the use of treatment targeting the cholinesterase system in patients with mild to moderate AD, and suggest that these patients may benefit from long-term treatment with ChEIs to slow the progression of cognitive impairment. Several factors support the validity and...
Magnetic resonance imaging-based volumetry differentiates idiopathic Parkinson's syndrome from multiple system atrophy and progressive supranuclear palsy. By using three-dimensional magnetic resonance imaging-based volumetry, we studied atrophy of the caudate nucleus, putamen, brainstem, and cerebellum in pat...
Alternative treatment approaches for mitigating cognitive problems are greatly needed in this population. To date, cognitive rehabilitation and exercise training have been identified as possible candidates for treating MS-related cognitive impairment; however, cognitive dysfunction is still often considered to...
These findings have implications for the use of treatment targeting the cholinesterase system in patients with mild to moderate AD, and suggest that these patients may benefit from long-term treatment with ChEIs to slow the progression of cognitive impairment. Several factors support the validity and...
These nonconventional MR-derived metrics include measures of CNS atrophy, magnetization transfer MRI, DWI, proton MR spectroscopy, and functional MRI (fMRI). These techniques are now being used to better understand the natural history of MS and to assess the effects of treatment. CNS Atrophy ...