Due to MSA significance, many MSA algorithms have been developed. Unfortunately, constructing accurate multiple sequence alignments is a computationally intense and biologically complex task, and as such, no cu
RNAcode estimates the significance of a coding prediction by sampling a given number of random alignments. Default is 100 which gives reasonably stable p-values that are useful for assessing the relevance of a prediction. --stop-early -s Setting this option stops the sampling process as soon ...
Generally speaking, the alignment scores of MSACompro are significantly higher than all the alignment methods without using structural information and MUMMALS of using structural information in all but one case according to the significance threshold of 0.05. The exception is that MSACompro's TC ...
LocalAlignment(Smith-Watermanalgorithm) ImportantTerms GapPenalty(Opening,Extended) PID,Similarity/DissimilarityScore SignificanceScore(e.g.Z&E) Aligningbiologicalsequences •Nucleicacid(4letteralphabet+gap) TT-GCAC TTTACAC •Proteins(20letteralphabet+gap) ...
Results were plotted using normalized permutation thresholds (nLOD) with a threshold of statistical significance based on 1,000 permutations (blue horizontal line). B Three-way phenotype × genotype plots for pCOL and pPUST show the contribution of Rps6, Rps7, and Rps8 to resistance to P. ...
O'Halloran DM, Fitzpatrick DA, McCormack GP, Mclnerney JO, Burnell AM: The Molecular Phylogeny and Functional Significance of a Nematode Specific Clade of Heterotrimeric G-protein α-Subunit Genes. J Mol Evol. Robertson HM: Two large families of chemoreceptor genes in the nematodes Caenorhabditis...
focused on full-length L1 copies to keep the specificity high, but truncated L1s and other types of TEs can also exist in centromeres. Recent efforts for end-to-end chromosome assemblies19,20constructed full centromeric sequences and will help uncover the biological significance of centromeric TEs...
The optimal alignment or the weighted minimum edit distance between two DNA or amino acid sequences for a given set of weights is computed by classical d... D Gusfield,K Balasubramanian,D Naor - 《Algorithmica》 被引量: 248发表: 1994年 Statistical significance in biological sequence analysis ...
formultiplesequencealignmentaidedbyquality analysistools JulieD.Thompson,TobyJ.Gibson 1 ,FrédéricPlewniak,FrançoisJeanmougin*and DesmondG.Higgins 2 InstitutdeGenetiqueetdeBiologieMoleculaireetCellulaire(CNRS/INSERM/ULP),BP163,67404IllkirchCedex,
Unless otherwise stated, all data are mean ± SEM and representative of at least two independent experiment done in triplicates and statistical significance assessed by using unpaired Student’s t test (*p < 0.05; **p < 0.01; ***p < 0.001). N.D. not detected Full size...