Significance of Sequence Alignment Scoresdoi:10.1007/978-3-540-48426-4_7Alexander IsaevSpringer Berlin Heidelberg
One way to do this is to take random permutations of the fly sequence. This can be done with the randperm function. Then calculate the global alignment of these random sequences against the human protein and look at the statistical significance of the scores. Initialize the state of the ...
For instance, using a BLOSUM62 scoring system for local sequence alignment, we compute that the p-value of a score of 6000 for the alignment of two sequences of length 1000 is (3.4 +/- 0.3) x 10(-1314). Further, we show that the extreme value significance statistic for the local ...
Non-Conservative Pairwise Statistical Significance of Local Sequence Alignment Using Position-Specific Substitution Matrices Choudhary, and X. Huang. Non-conservative pairwise statistical significance of local sequence alignment using position-specific substitution ma- trices. In ... A Agrawal,AN Choudhar...
Since the degree of similarity is usually assessed by the sequence alignment score, it is necessary to know if a score is high enough to indicate a biologically interesting alignment. A powerful approach to defining score cutoffs is based on the evaluation of the statistical significance of ...
In sequence alignment, if i is aligned to i ' and j>i, then j cannot be aligned to j'
Our methods are illustrated in detail using a 1.49 Mb genomic region. Preliminary results using all of human chromosome 22 indicate that these techniques will work for the entire human genome. 展开 关键词: DNA sequence alignment p-values of interspecies matches evolutionary rate hidden Markov model...
The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078–2079 (2009). Article PubMed PubMed Central Google Scholar Wagner, G. P., Kin, K. & Lynch, V. J. Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples. Theory Biosci. 131, ...
DY and XF carried out the molecular genetic studies, participated in the sequence alignment and drafted the manuscript. PY, QW carried out the immunoassays. FY, SY and BL participated in the sequence alignment. ZL participated in the design of the study and performed the statistical analysis. GZ...
Statistical significance of hierarchical multi-body potentials based on Delaunay tessellation and their application in sequence-structure alignment. Third, the utility of the multi-body potential is tested on a test set of 12 same-length pairs of proteins of known structure for two protocols: Sequenc...