Multiple sclerosis: Phases of disease improvement unrelated to relapsesPublication » Multiple sclerosis: Phases of disease improvement unrelated to relapses..doi:10.1038/nrneurol.2012.186Oluf AndersenPubMedNature Reviews Neurology
Multiple sclerosis: Two-stage disease The pathogenesis of multiple sclerosis consists of an inflammatory and neurodegnerative phase. Better understanding of these stages has aided the development of specific therapeutic targets. L Steinman - 《Nature Immunology》 被引量: 916发表: 2001年 ...
At later stages of multiple sclerosis, there is a massive influx of immune cells at the lesion in the CNS, including T cells, B cells, and macrophages. In human lesions of multiple sclerosis, macrophages and CD8+ T cells also inflict damage on blood vessels, where the result is a breakdow...
Evidence supports a behaviourally relevant role for neuroplasticity—which is preserved despite widespread pathology—in multiple sclerosis (MS) across all patient ages, stages and phases of the disease Together with adaptive plasticity, maladaptive plasticity can occur in brain systems owing to disuse of...
Multiple sclerosis According to the French neurologistsDoyon and Marsot-Dupuch (2002), 40% of patients suffering frommultiple sclerosishaveneuropathyof thetrigeminal nerve; in 10% of cases this is the first symptom.Multiple sclerosisis difficult to diagnose in its early stages. ...
Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain 2002;125(pt 10)2342- 2352PubMedGoogle ScholarCrossref 22. De Stefano NNarayanan SFrancis GS et al. Evidence of axonal damage in the early stages of ...
system. Myelin not only increases the cross-sectional diameter of the nerve axon (Figure 1A), which increases conduction velocity, but also contributes protectively and trophically to the health of the axon.51 Disruption of these relationships appears at the earliest stages of multiple sclerosis.3...
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. This disorder is a heterogeneous, multifactorial, immune-mediated disease that is influenced by both genetic and environmental factors. In most patien...
Multiple sclerosis pathogenesis in both relapsing and progressive disease. Scheme representing the major cells and molecules that play a role in the two different stages of MS. The dashed line allows comparison of the differences between relapsing and progressive MS. Arrows indicate release, while inhi...
We review the current state of knowledge of remyelination in multiple sclerosis (MS), concentrating on advances in the understanding of the pathology and t