Multiple sclerosis: Phases of disease improvement unrelated to relapsesPublication » Multiple sclerosis: Phases of disease improvement unrelated to relapses..doi:10.1038/nrneurol.2012.186Oluf AndersenPubMedNature Reviews Neurology
Multiple sclerosis is the prototype inflammatory autoimmune disorder of the central nervous system and, with a lifetime risk of one in 400, potentially the most common cause of neurological disability in young adults. As with all complex traits, the disorder results from an interplay between as ye...
Multiple sclerosis According to the French neurologistsDoyon and Marsot-Dupuch (2002), 40% of patients suffering frommultiple sclerosishaveneuropathyof thetrigeminal nerve; in 10% of cases this is the first symptom.Multiple sclerosisis difficult to diagnose in its early stages. ...
demyelination, and neurodegeneration that occur in multiple sclerosis since the topic was last reviewed in the Journal.1 Accordingly, the available clinical strategies for the management of the disease have widened (Table 1).2 However, the treatment options for the disease...
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represent an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis have sho
Evidence supports a behaviourally relevant role for neuroplasticity—which is preserved despite widespread pathology—in multiple sclerosis (MS) across all patient ages, stages and phases of the disease Together with adaptive plasticity, maladaptive plasticity can occur in brain systems owing to disuse of...
The classification of multiple sclerosis (MS) into the two distinct phases of relapsing–remitting and progressive, including primary progressive and secondary progressive phenotypes (PPMS and SPMS, respectively) has long been accepted; however, there are several unmet needs associated with this particular...
Multiple sclerosis; POMS: Pediatric-onset MS; PPMS: Primary progressive MS; ON: Optic neuritis; OR: Odds ratio; RRMS: Relapse remitting MS; SC: Subcutaneous; SLE: Systemic lupus erythematosus; SPMS: Secondary progressive MS; SWI: Susceptibility-weight imaging; TDT: Transmission disequilibrium test;...
At later stages of multiple sclerosis, there is a massive influx of immune cells at the lesion in the CNS, including T cells, B cells, and macrophages. In human lesions of multiple sclerosis, macrophages and CD8+ T cells also inflict damage on blood vessels, where the result is a breakdow...
Nevertheless, in general during most EAE experiments three principal phases or stages of pathogenesis may be identified (Kuerten and Lehmann, 2011): (i) pre-immunisation phase, during which potentially autoreactive but currently quiescent T cells circulate in normal animals; (ii) induction phase (0...