Objective: To dissect cellular heterogeneity and understand molecular changes in inflammatory cells, neurons and glial cell types by single-cell genomics of MS and control brain samples.Background: Multiple sclerosis (MS) is a chronic inflammatorydemyelinating disease with early relapsing-remitting and ...
Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192, 393–404 (2000). PubMed PubMed Central Google Scholar Machado-Santos, J. et al. The ...
reported the different molecular expression pattern in the components constituting the blood–brain barrier and blood–nerve barrier, and suggested that the blood–nerve barrier might have a distinct mechanism for T cell migration.doi:10.1038/nrneurol.2009.76Senior...
B cells in multiple sclerosis play different roles, acting as both drivers and regulators of the disease. The pathogenic involvement of B cells is proved by the beneficial effect accomplished by B cell depletion therapy. This type of therapy is performed with anti-CD20, such asRituximab, and pr...
, et al. short-lived plasma blasts are the main b cell effector subset during the course of multiple sclerosis brain , 128 ( pt 7 ) ( 2005 ) , pp. 1667 - 1676 n.d. chiaravalloti , j. deluca cognitive impairment in multiple sclerosis lancet neurol. , 7 ( 12 ) ( 2008 ) , pp...
Multiple sclerosis (MS) is thought to be an autoimmune disease; however, the exact cause is not known. Early signs and symptoms of MS are fatigue, bladder and bowel problems, vision problems, and numbness, tingling, or pain in certain areas of the body.
Multiple sclerosis (MS) is an inflammatory disorder that causes damage in the brain and spinal cord, which can lead to a range of symptoms, including fatigue, depression, muscle spasms, and difficulty regulating the bladder and bowels. Several strategies using stem cells — self-renewing cells ...
Cell-derived microparticles are secreted in response to cell damage or dysfunction. Endothelial and platelet dysfunction are thought to contribute to the development of multiple sclerosis (MS). Our aim here is, first, to compare the presence of micropart
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when,
Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of CSF leukocytes. Multiple sclerosis (MS) – an autoimmune disease of the CNS – increases transcriptional diversity in blood, but increases cell type diversity in CSF including a higher ...