SMM also shows an M protein on SPEP and is similar to MGUS in its lack of clinical manifestations but is more likely to progress to symptomaticmyeloma; progression to MM is 10% per year for the first 5 years, 3% per year for the subsequent 5 years, and 2% per year for the 5 years...
Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by CD8+ T cells. Understanding how CD28 activat
A stem cell transplant is a common treatment for multiple myeloma. If you’re able to have one, you’ll get induction therapy followed by a high dose of a chemotherapy drug to kill as many cancer cells as possible. Or your doctor might give you a combination of some of the other medici...
Light chain cast nephropathy (LCCN) is the most common renal disease caused by multiple myeloma (MM). In addition to ordinary light chain protein casts, there are a few rare casts with unique shapes, including light chain amyloid casts (LCAC) and light chain crystal casts (LCCC). Case prese...
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We calculated thep-values of Fig.4b, fto check whether the overlap is significant by comparing the overlap between different cell types using Fisher’s exact test. Data availability All essential codes used for analysis are available at GitHub (http://github.com/ChengLiLab/myeloma). The Gene Ex...
multiple myeloma; MYC; microRNA; miR-22; lenalidomide; NK cells Graphical Abstract1. Introduction Multiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of malignant plasma cells in the bone marrow (BM), associated with bone disease, serum monoclonal gammopathy, ...
Minimal residual disease (MRD) status is now considered as one of the most relevant prognostic factors in multiple myeloma (MM) while MRD negativity became an important endpoint in clinical trials. Here, we report the results of the first study evaluating the reproducibility of high-sensitivity flo...
Multiple myeloma, also known as Kahler's disease, is a type ofblood cancer. There's no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multipl...
they have been doing this research for 10 years to find a blood test for detecting different cancers. From the results obtained from the blood test, the doctor will even be able to know the multiple myeloma is at which stage and the best type of drug for the patient to use to treat it...