These results are important in showing that significant anti-myeloma effects may be achieved by the use of IMiDs, even in myeloma cells that are resistant to standard chemotherapy effects. Additionally, these findings reveal that two mechanisms are used by thalidomide and IMiDS to ac...
Data Support Real-World Use of Ide-cel in R/R CNS Multiple Myeloma By Jonah Feldman December 12th 2024 Real-world data show that CAR T-cell therapy may be considered for eligible patients with relapsed/refractory multiple myeloma harboring CNS involvement. ORR, DOR, and Safety Outcomes with Li...
A new study finds even if renal function is restored, patients who have severe renal impairment when diagnosed with multiple myeloma have lower overall survival rates. Severe renal impairment (RI) is associated with decreased rates of survival among patients with multiple myeloma (MM), even if ren...
The genetic architecture of multiple myeloma 10.1038/nrc3257 View in Scopus Google Scholar 10 A.C. Rawstron, F.E. Davies, R.G. Owen,et al. B-lymphocyte suppression in multiple myeloma is a reversible phenomenon specific to normal B-cell progenitors and plasma cell precursors ...
et al. MicroRNA and multiple myeloma: from laboratory findings to translational therapeutic approaches. Curr. Pharm. Biotechnol. 15, 459–467 (2014). 7. Di Martino, M. T. et al. Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. ...
Reference:Plasma cell myeloma (multiple myeloma) Board review style question #3 Which of the following findings would most strongly favor the presence of a neoplastic plasma cell process rather than a reactive plasma cell proliferation?
Findings of whole body computed tomography compared to conventional skeletal survey in patients with monoclonal plasma cell disorders - a study of the International Myeloma Working Group [Abstract]. Blood 2016;128:4468. 2 Hinge M, Andersen KT, Lund T, et al. Baseline bone involvement in multiple...
Multiple myeloma (MM) is an incurable haematological malignancy, caused by the uncontrolled proliferation of plasma cells within the bone marrow (BM). Obesity is a known risk factor for MM, however, few studies have investigated the potential of dietary
Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by CD8+ T cells. Understanding how CD28 activat
Their findings indicated that CD24 was found to be expressed in myeloma cells at relapse following BCMA CAR-T cell therapy22. In the tumor microenvironment, CD24 is an important checkpoint molecule controlling the innate immune response23,24. CD24 on tumor cells binds to sialic-acid-binding ...