Selective inhibitors of nuclear export (SINE)help suppress protein movement from the nucleus of the cancer cell. The drugselinexor(Xpovio) is the only one in this class and is used for treating people with relapsed or refractory multiple myeloma. Antibody-drug conjugatesare a newer class of drug...
Recent insights into the biological basis of myeloma have resulted in several new drugs becoming available. Thalidomide, bortezomib and lenalidomide have each improved the response to therapy, but they are expensive. Future challenges include optimising the sequence of these drugs, refining their ...
The meaning of MULTIPLE MYELOMA is a disease of bone marrow that is characterized by the presence of numerous myelomas in various bones of the body.
used because most immunoglobulins migrate in the γ-region of an electrophoresis gel. However, some immunoglobulins, especially immunoglobulin A (IgA) and IgM, migrate to the β-region. Occasionally, biclonal or other atypical electrophoretic patterns may be seen with multiple myeloma as a result ...
New drugs in multiple myeloma. Curr. Opin. Support. Palliat. Care 2, 204-210.Berenson JR, Yellin O. New drugs in multiple myeloma. Curr Opin Support Palliat Care. 2008;2:204-10Berenson JR, Yellin O (2008) New drugs in multip...
Mechanisms of action and drug resistance of the most used classes of drugs in Multiple Myeloma. Mechanism of Action Inhibition of proteasome activity; inhibition of NF-κB; induction of apoptosis by activating caspase-8 and caspase-9; upregulation NOXA; down-regulation of adhesion molecules [52,...
Proteasome inhibitors stop the process that eats up extra proteins in cells. Myeloma cells make lots of proteins. When they build up, the cancer cells die. These drugs include: Bortezomib(Velcade) Carfilzomib(Kyprolis) Ixazomib(Ninlaro) Histone deacetylase (HDAC) inhibitors, likepanobinostat(Farydak)...
I would love to see a cure for multiple myeloma. The disease is very resistant to drugs, and the recurrence rate is high. If we could get to a point where we stop it completely, that would be remarkable. And, of course, if any of the therapies that we discover or develop might play...
“The diagnosis, workup, and treatment of myeloma have dramatically changed over the past 10 years. The therapeutic goal is to obtain deep remissions that translate into improved progression-free and overall survival. With combination therapy using immunomodulatory drugs, proteasome inhibitors, monoclonal...
Multiple myeloma treatment used within 1 year after diagnosis, by year of diagnosis. Note: novel treatment include: bortezomib, carfilzomib, lenalidomide, panobinostat, pomalidomide and thalidomide. Non-novel treatment include: arsenic trioxide, bendamustine, busulfan, cisplatin, cyclophosphamide, doxorubicin...