The phase III trials in multiple myeloma and AML did not meet their primary endpoints. Phase I and II trials are also underway or have been completed for a range of other cancer types. Genta and sanofi-aventis (formerly Aventis) entered into a collaboration agreement in 2002; however, this ...
Chemotherapyis treatment with cancer-fighting drugs. Because these medicines go into your bloodstream and can reach all parts of your body, they’re a good choice to destroy myeloma cells. You might get chemotherapy as a shot in a vein or take it in pill form. Your doctor may use chemother...
When it's used as a drug, it can slow the growth of myeloma cells. You might take interferon if you've had treatment and are in remission, which means your doctor can't spot any signs of myeloma in your body. Corticosteroids. These drugs can help other treatments work better. When ...
Fig. 1. Pathogenies of Multiple Myeloma: Circulating tumor cells (CTC) and minimal residual disease (MRD) clones represent aggressive clones driving disease dissemination and resistance. (CTCs: circulating tumor cells, N-PC: normal plasma cells, NK: NK- cells, B: B-lymphocytes, CD8: CD8 + ...
Lipid reprogramming is emerging among the metabolic hallmarks of cancer, and can be also exploited by myeloma PCs to meet the requirements for survival, proliferation, chemoresistance and immune evasion. It has now become clear that the BMM can contribute to the metabolic rewiring of the MM cells...
refractory multiple myelomaIntroduction: The overall survival of patients with multiple myeloma has improved with the advent of novel agents; however, multiple myeloma remains incurable. Combinations of standard-of-care agents such as immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal ...
used because most immunoglobulins migrate in the γ-region of an electrophoresis gel. However, some immunoglobulins, especially immunoglobulin A (IgA) and IgM, migrate to the β-region. Occasionally, biclonal or other atypical electrophoretic patterns may be seen with multiple myeloma as a result ...
“The diagnosis, workup, and treatment of myeloma have dramatically changed over the past 10 years. The therapeutic goal is to obtain deep remissions that translate into improved progression-free and overall survival. With combination therapy using immunomodulatory drugs, proteasome inhibitors, monoclonal...
Despite the significant advances in the treatment of multiple myeloma (MM), this disease is still considered incurable because of relapse and chemotherapy resistance, underscoring the need to seek novel therapies with different mechanisms. Anlotinib, a n
Monoclonal antibodies target certain proteins found on myeloma cells. What Monoclonal Antibodies Are Used to Treat Multiple Myeloma? There are a handful, most of which your doctor gives you through an IV in your vein. They are: Elotuzumab (Empliciti). This drug does two things: It spurs the ...