However, invasive bone marrow (BM) biopsies cannot be performed frequently and multifocally to assess the spatially heterogenous tumor tissue. Therefore, the goal of this study was to establish an automated framework to predict local BM biopsy results from magnetic resonance imaging (MRI).MATERIALS ...
Patients were classified as having MGUS (n = 20) or symptomatic MM (n = 25) according to the International Myeloma Working Group criteria [14] or benign hematological disorders (n = 10) (Table 1). Bone marrow was sampled by both aspiration and biopsy of the posterior iliac ...
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging with current biological approaches. Here, we report ...
Bone marrow biopsies are the gold standard for diagnosing and monitoring the progression of multiple myeloma, but these procedures are far too invasive to perform at every patient visit. Scientists from the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard, however, have shown...
After your test results come in, your doctor may want to do a bone marrow biopsy. They'll put a needle into a bone, usually in your hip, and take a sample of marrow to check the number of plasma cells in it. You might get imaging tests. X-rays can show spots of bone damaged by...
A cancer that affects plasma cells (white blood cells in bone marrow which produce antibodies). MM causes overproduction of plasma cells, often causing overproduction and imbalances in antibodies.myelomacarlenalidomidedararevlimidmrdtermcarvyktidexmaintenancefasprobonneabecmaevusheldbispecifictransplantsctr...
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. [1] First described in 1848, MM is part of...
What is Multiple Myeloma? Micrograph of myeloma neoplasm from a bone marrow biopsy. The blood contains several different types of cells, each with an important function. All blood cells develop in the bone marrow, the spongy substance within our bones. The originator of all blood cells is an ...
Multiple Myeloma Multiplemyelomais a multifocal malignant proliferation of monoclonal plasma cells that occurs most commonly in men older than 60 years. Diagnosis is confirmed by bone biopsy or by demonstratingBence Jones proteins(free light chains) in urine ormonoclonal gammopathyin serum. Although it...
Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting CD38 have shown encouraging efficacy in treating MM, either as a monotherapy agent or in...