Multiple myeloma, also known as Kahler's disease, is a type of blood cancer. There's no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multi...
This is a cancer of the plasma cells in bone marrow. Plasma cells are a type of white blood cell that makes antibodies. Myeloma cells spread through the bone marrow. They can damage your bones and crowd out healthy blood cells. These cells also make antibodies that can't fight off infecti...
Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research Foundation CoMMpass Study. Patients with multip...
MULTIPLE myelomaBLOOD cell countPLASMA cell diseasesBLOOD protein electrophoresisBONE marrow examinationERYTHROCYTESVERTEBRAE injuriesHaemophagocytosis by malignant cells (in particular erythrophagocytosis) is a well-known phenomenon in acute myelomonocytic or monocytic leukaemia with t(8;16)(p11.2;p13.3). ...
Multiple myeloma (MM) remains an incurable hematological malignancy disease characterized by the progressive dysfunction of the patient’s immune system. In this context, immunotherapy for MM has emerged as a prominent area of research in recent years. V
Cancer stem cells(CSCs) are a small proportion of tumor cells with the property of stem cells in the tumor tissue;they are capable of self-renewal,multi-lineage differentiation and serve as the source of tumor cells and tumor tissues.The discovery of multiple myeloma CSCs and the study on it...
Myeloma is a cancer of the plasma cells of the blood. Symptoms include early osteoporosis, hypercalcemia, hyperviscosity of the blood, low red and white blood cell counts, low platelet count, cryoglobulinemia, and amyloidosis. Tests to diagnose multiple
Blood 92:2908–2913 CAS PubMed Google Scholar Yaccoby S, Epstein J (1999) The proliferative potential of myeloma plasma cells manifest in the SCID-hu host. Blood 94:3576–3582 CAS PubMed Google Scholar Cox CV, Evely RS, Oakhill A, Pamphilon DH, Goulden NJ, Blair A (2004) ...
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients’ survival in the past two decades, MM remains la
Multiple Myeloma Multiplemyelomais a multifocal malignant proliferation of monoclonal plasma cells that occurs most commonly in men older than 60 years. Diagnosis is confirmed by bone biopsy or by demonstratingBence Jones proteins(free light chains) in urine ormonoclonal gammopathyin serum. Although it...