Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension? BMC pulmonary medicine. 2011;11:30.Hennigs JK, Keller G, Baumann HJ, Honecker F, Kluge S, Bokemeyer C, et al. Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-...
multityrosine针对血管内皮生长因子受体激酶抑制剂 翻译结果2复制译文编辑译文朗读译文返回顶部 针对血管内皮生长因素感受器的一种 multityrosine kinase 抑制剂 翻译结果3复制译文编辑译文朗读译文返回顶部 multityrosine 激酶抑制剂抗血管内皮生长因子受体 翻译结果4复制译文编辑译文朗读译文返回顶部 一个multityrosine激酶抑制剂...
Objective To explore the protective role of the receptor tyrosine kinase inhibitor in chondrocyte in vitro. 目的通过对体外培养软骨细胞的实验研究,探寻受体酪氨酸激酶抑制剂对软骨细胞在细胞分子水平的影响及其可能机制。 更多例句>> 4) Tyrosine kinase inhibitors 酪氨酸激酶抑制剂 1. Progress of epidermal ...
This is a tentative inference that multi- tyrosine kinase inhibitor targeting EGFR, HER2, and VEGFR2 may be a viable treatment for cancer. Through optimization of the hit compound, we obtained DCLAK11, a single compound that inhibits both EGFR/HER2 as well as VEGFR tyrosine kinases. When ...
The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther 2013; 12: 131–40. 28 Zhou YF, Chen Y, Tong LJ, Xie H, Wen WW, Zhang J, et al. AL3810, a multi-tyrosine kinase inhibitor, ...
Therefore, the intrinsic cytotoxicity of SKLB610, a multi-targeted inhibitor of tyrosine kinases, was examined in multiple pairs of drug-sensitive cell lines and the corresponding ABCB1- or ABCG2-overexpressing multidrug-resistant sublines. The extent of cellular resistance to SKLB610 mediated by ...
Pazopanib (GW786034) is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1,-2, and-3, platelet-derived growth factor receptor-α, platelet-derived growth factor receptor-β, and c-kit. Preclinical evaluation has revealed excellent antiangiog...
Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro and human CRC xenografts in vivo. The effect of E7080 on cell viability was examined on 10 human CRC cell lines and human endothelial cells (...
Inhibitor Tyrosine kinase target Neoplasm(s) targeted Clinical status Gefitinib (Iressa, ZD1839) EGFR Lung, breast Approved Erlotinib (Tarceva, OSI774) EGFR Lung Approved Lapatinib (Tykerb, GW-572016) ErbB1, ErbB2 Breast, RCC, gastric, HN, NSCLC Approved Canertinib (CI-1033) EGFR, ErbB2, Er...
et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res. 10, 784–793 (2004). 18. Chiu, Y. L. et al. Exposure-response (...