multityrosine针对血管内皮生长因子受体激酶抑制剂 翻译结果2复制译文编辑译文朗读译文返回顶部 针对血管内皮生长因素感受器的一种 multityrosine kinase 抑制剂 翻译结果3复制译文编辑译文朗读译文返回顶部 multityrosine 激酶抑制剂抗血管内皮生长因子受体 翻译结果4复制译文编辑译文朗读译文返回顶部 一个multityrosine激酶抑制剂...
tyrosine kinase inhibitor.Different tyrosine kinase inhibitors have various mechanisms to achieve selectivity,while differences in gene expression exist between tumor and stromal cells.Considering these aspects,one type of inhibitor can generally not be preferred above the other,but will depend on the ...
生化机理MDK74978(多激酶抑制剂 I)是一种多激酶抑制剂。 储存温度-20°C储存 运输条件超低温冰袋运输 产品介绍 Multi-kinase inhibitor 1 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与c-Kit,PDGF-R,Bcr-abl 活性相关的疾病。
Human malignancies are often the result of overexpressed and constitutively active receptor and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor-driven pathways. Several tyrosine kinases (ie, EGFR, FGFR, PDGFR, VEGFR), are aberrantly activated in most common tumors,...
Pazopanib (GW786034) is a second-generation multitargeted tyrosine kinase inhibitor against vascular endothelial growth factor receptor-1,-2, and-3, platelet-derived growth factor receptor-α, platelet-derived growth factor receptor-β, and c-kit. Preclinical evaluation has revealed excellent antiangiog...
Different tyrosine kinase inhibitors have various mechanisms to achieve selectivity, while differences in gene expression exist between tumor and stromal cells. Considering these aspects, one type of inhibitor can generally not be preferred above the other, but will depend on the specific genetic ...
Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung can... Combining the Multitargeted Tyrosine Kinase Inhibitor Vandetanib with the Antiestrogen Fulvestrant Enhances Its Antitumor Effect in Non-small Cell ...
et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res. 10, 784–793 (2004). 18. Chiu, Y. L. et al. Exposure-response (...
Therefore, the intrinsic cytotoxicity of SKLB610, a multi-targeted inhibitor of tyrosine kinases, was examined in multiple pairs of drug-sensitive cell lines and the corresponding ABCB1- or ABCG2-overexpressing multidrug-resistant sublines. The extent of cellular resistance to SKLB610 mediated by ...
Novel FGFR inhibitor ponatinib sup- presses the growth of non-small cell lung cancer cells overexpressing FGFR1. Oncol Rep. 2013;29(6):2181–2190. 14. Zhang J, Zhou Q, Gao G, et al. The effects of ponatinib, a multi-targeted tyrosine kinase inhibitor, against human U87 malignant ...