Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis Author links open overlay panelQing Zhong, Wenhua Gao, Fenghe Du, Xiaodong WangShow more Add to Mendeley Share Cite https://doi.org/10.1016/j.cell.2005.06.009Get rights and ...
Although Parkin is undoubtedly the most important E3 ligase in mitophagy, recent studies have also found that other E3s are involved in mitophagy (Figure 2B, andTable IinBox 2). HUWE1 (also namedMule, ARF-BP1, LASU1, or HECTH9) is an abundant HECT-type E3 that can catalyze multiple type...
The transcription factor Miz1 negatively regulates TNF-induced JNK activation and cell death by suppressing TRAF2 K63-polyubiquitination; upon TNF stimulation, the suppression is relieved by Mule/ARF-BP1-mediated Miz1 ubiquitination and subsequent degradation. It is not known how Mule is activated by...
Diabetologia (2014) 57:1889–1898 DOI 10.1007/s00125-014-3295-8 ARTICLE Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions Linyuan Wang & Cynthia T. Luk & Stephanie A. Schroer & Alannah M. Smith & Xie Li ...
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell. 2005;121:1071–83. Article CAS PubMed Google Scholar Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R, et al. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential ...
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes & development 27, 1101–1114 (2013). Article CAS Google Scholar Hao, Z. et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B ...
A newly discovered ubiquitination molecule HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1 [also known as MULE or ARF-BP1]) is a critical regulator of p53-dependent apoptosis. However, its role in islet homeostasis is not entirely clear.We generated mice with ...
dichotomous ro1e of pancreatic huwe1 mu1e arf bp1 in modu1ating b ce11 apoptosis in mice under physio1ogica1 and genotoxic conditions dichotomous ro1e of pancreatic huwe1 mu1e arf bp1 in modu1ating b ce11 apoptosis in mice under physio1ogica1 and genotoxic conditions... Linyuan Wang &...
(2005) describe a new E3 ligase, ARF-BP1/Mule, which targets two very different substrates, p53 and Mcl-1, with completely different cellular outcomes.doi:10.1016/j.cell.2005.06.018Ayelet ShmueliMoshe OrenElsevier Inc.CellShmueli, A. and Oren, M. (2005) Life, death, and ubiquitin: ...
et al. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121, 1071–1083 (2005). 18. Iritani, B. M. et al. Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J. 21, 4820–4830 (2002). ...