ARF-BP1, a HECT domain-containing E3 ubiquitin ligase, interacts with ARF and p53. Its ubiquitin ligase activity is inhibited by ARF. Inactivation of ARF-BP1 stabilised p53 and induced apoptosis. Notably, inactivation of ARF-BP1 also caused cell growth repression in p53-null cells and breast ...
p14 ARF、ARF-BP1、c-myc在肝细胞癌中的表达及意义 维普资讯 http://www.cqvip.com
Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis Author links open overlay panelQing Zhong, Wenhua Gao, Fenghe Du, Xiaodong WangShow more Add to Mendeley Share Cite https://doi.org/10.1016/j.cell.2005.06.009Get rights and ...
A newly discovered ubiquitination molecule HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1 [also known as MULE or ARF-BP1]) is a critical regulator of p53-dependent apoptosis. However, its role in islet homeostasis is not entirely clear.We generated mice with ...
Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions 来自 国家科技图书文献中心 喜欢 0 阅读量: 21 作者:Gaisano,Schroer,A S.,Cai,P E.,Luk,T C.,Wang,Smith,M A....
制造商 : Microsemi Corporation (Microchip ) 封装/规格 : TO-247CS 产品分类 : 晶体管 Datasheet: ARF463BP1 Datasheet (PDF) RoHs Status: Lead free / RoHS Compliant 库存: 29688 Share: Pinterest LinkedIn WhatsApp Facebook Line X 分享 对比产品 数量 加入BOM 询价 ...
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《Sema3E双重调控PIP5KIβ-Arf6和SH3BP1-Rac1信号保护脑梗死后血脑屏障的研究》是依托华中科技大学，由李亚男担任项目负责人的青年科学基金项目。中文摘要 脑梗死后缺血脑组织水肿是导致患者急性期死亡最重要的原因之一。我们发现: 大鼠脑梗死后3-7天为水肿高峰期，与Sema3E/Plexin-D...
《Caspases切割ARF-BP1调控p53信号通路的机制》是依托厦门大学，由张四清担任项目负责人的面上项目。项目摘要 ARF-BP1是抑癌基因p53的主要负调控者之一，通过泛素化修饰降解p53. 但对ARF-BP1的调控以及这些调控如何影响p53的功能却知之甚少，亟待深入研究。本申请项目发现ARF-BP1是一个新的重要caspase底物。caspase切割...