MTHFR converts 5, 10-methylene-THF into 5-methyl-THF. Polymorphism of MTHFR C677T leads to a reduction in enzyme activity, which may lead to an increased concentration of plasma homocysteine and lower levels of serum folate, particularly in those with low folate intake [6]. MTR catalyzes ...
The results of this study have shown that interactions among homocysteine metabolism gene polymorphisms lead to dramatic elevations in the folate deficiency risk. Keywords: MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G; folate deficiency 1. Introduction Recently, a large-scale randomized ...