② 667C>T:指的是MTHFR基因上677位点可能会发生C→T突变,即碱基胞嘧啶(C)被胸腺嘧啶(T)所取代。 ③ 基因型:指的是MTHFR 677位点上存在的三种多态性,即667CC型(野生型)、667CT型(杂合突变型)、667TT型(纯合突变型)。突变位点越多,酶活力下降越厉害。 03 ...
Statistically significant association was observed for MTHFR CT genotype (IS-Pooled: OR = 429; p = 5.01 x 10(-5); IS-Males: OR = 4.13; p = 0.001; IS-Females: OR = 8.62; p = 0.027; IS-Large Vessel Disease (LVD)-Pooled: OR = 4.14; p = 0.0002) and T allele (IS-Pooled: ...
中国人群高血压与HHcy 同时存在,脑卒中风险增加11.7倍[7]。研究显示:MTHFR C677T突变可导致MTHFR酶活性下降,其中CT型、TT型人群的酶活性分别为C/C型的65%和30%,因此,TT型人群可能最易患HHcy。并且中国人群MTHFR C677T 突变纯合基因型的频率显著高于...
The frequency of co-occurrence of MTHFR 677 CT/1298 CC genotypes was significantly higher in the patients compared to controls ( P <0.05) and was associated with increased risk of hypertension (OR=3.54, 95%CI: 0.37–4.30). Subjects with MTHFR 1298 CC genotype had significantly higher ...
No statistically significant difference was found in the genotype distribution of MTHFR C677T between males and females (P=0.802). Among different age groups (except the age group of ≥70 years), MTHFR 677CT genotype was predominant and its genotype frequencies in the group of < 30 years, ...
The genotype and allelic distribution were compared between 2 groups. The relationship between gene polymorphism and the occurrence of coronary heart disease was investigated. RESULTS: CC, CT and TT genotype in MTHFR gene C677T site, AA, AC and CC genotype in MTHFR gene A1298C site as well ...
脑白质病变(white matter lesions, WML)是脑小血管病的一种常见类型,指头颅影像学检查所示脑室旁和(或)半卵圆中心的斑片状或弥散状改变,CT呈低密度,MRI T 2和液体衰减反转恢复序列(fluid-attenuated inversion recovery, FLAIR)呈高信号 [ 1 ]。WML可导致中老年人认知障碍(包括记忆力、计算力、执行功能下降) ...
名不育症患者和1958名健康男性的MTHFR基因677位点多态性与健康状态的统计分析，发现：MTHFR基因是亚洲男性不育的易感基因，亚洲男性MTHFR基因TT/CT型不育的风险是CC型的1.42倍；MTHFR基因TT/CT基因型男性精子缺乏的风险是CC型的1.55倍4。伊朗研究者对伊朗164名不育成年男性和328名 ...
05），and the HDL-C level was decreased（P<0.01）. Compared with CC genotype GDM patients，TT genotype GDM patients had higher TC and non-HDL-C levels（P<0.05）and lower HDL-C levels（P<0.01）. The levels of TG，TC，LDL-C and non-HDL-C in GDM patients with CT genotype were ...
The frequency of co-occurrence of MTHFR 677 CT/1298 CC genotypes was significantly higher in the patients compared to controls ( P <0.05) and was associated with increased risk of hypertension (OR=3.54, 95%CI: 0.37–4.30). Subjects with MTHFR 1298 CC genotype had significantly higher ...