2、 Melanie Kolz,et al.Meta-Analysis of 28141 individuals identifies common variants within five newloci that influence uric acid concentrations[J].PLOS genetics,2009,5(6):1-10. 3、 Abbas Dehghan, et al.Association of three genetic loci with uric acid concentration and risk ofgout: a ...
MTHFRMutationsHomocysteineThe common variants of the methylenetetrahydrofolate reductase (MTHFR) gene are related to the activity of the MTHFR enzyme and the concentrations of blood homocysteine (Hcy). This study was designed to investigate the associations of MTHFR in Chinese populations with early-...
This experiment aimed to investigate the allele frequency of the PTC taster gene (TAS2R38) in a small population, represented by the students in class. The genotype obtained from genomic analysis (via PCR and gel electrophoresis) confirmed that the genotypic result is consistent with the phenotypi...
Both MTHFR and COMT genes affect brain chemistry, immune health, inflammation, energy production, cardiovascular health and more. This cheek swab test can help determine if you have common variants of either gene. Both MTHFR and COMT genes are involved in the methylation pathway and testing their...
The MTHFR gene is responsible for producing an enzyme that plays a crucial role in processing amino acids, the building blocks of proteins. Mutations in this gene, particularly the C677T and A1298C variants, can reduce the function of this enzyme and subsequently affect the body's methylation...
First, a gene-based logistic regression analysis was performed across all common variants in the gene to assess cumulative evidence for association with toxicity. Second, analysis of each variant was performed using an allele- based Fisher's exact test, and with a logistic regression model, ...
MTHFR genetic variants: an example of gene-nutrient interaction and susceptibility to childhood acute lymphoblastic leukemia Author links open overlay panelDaniel Sinnett, Damian Labuda, Maja KrajinovicShow more Add to Mendeley Share Cite Get rights and content Under an Elsevier user license Open ...
The association between the MTHFR gene variants -mainly C677T but also A1298C-and CVD has been widely investigated in the general population and it is thought that individuals with the MTHFR677TT genotype had a significantly higher risk of CVD26,41,42,43. This association has also been a ...
Is the common 677C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis QJM, 90 (1997), pp. 111-115 View in ScopusGoogle Scholar 5 Shelnutt KP, Kauwell GP, Gregory JF III, Maneval DR, Quinlivan EP, Theriaque DW, Henderson ...
Stroke is a major global disability cause, and genetic variables for multifactorial illnesses like stroke are crucial for precision medicine. The purpose of this study is to see if genetic variants in the MTHFR gene are associated with a higher risk of i