HK013-G1 was designed to retain the Fc effector function through the adoption of the IgG1 Fc region. The ADCC reporter assay using the FcγRIIIa Jurkat effector HK013-G1 induced an obvious ADCC effect in MSLN-positive OVCAR3 cells in a dose-dependent manner, which was superior to that...
megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein ...
In this study, we evaluated the impact of genetic targeting of Tim3 and A2a receptors on the antitumor function of human mesothelin-specific CAR T cells (MSLN-CAR) in vitro and in vivo. Methods: Second-generation anti-mesothelin CAR T cells were produced using stand...
Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model Introduction: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies. However, its efficacy in solid tu... T Sol...
Function Waterproof Layer Multi Layers Pattern Wood Grain Color Red Certification CE Usage Household, Commercial Customized Non-Customized Installing Tg, Left and Right Plywood Eculyptus Mositrue 8%-10% Grade Ab, ABC, Abcd Transport Package Pallets ...
WPC Qi V1.2.4 FOD Function Dynamic Rectifier VRECT Improves the Load Transient Response Optimizes the dynamic efficiency for full load output Rectifier Overvoltage Clamp (VOVP=15V) Supports 20 V Maximum Input Over Temperature, Over Voltage and Over Current Protection ...
Function Remove Impurity, Grade Seed Size Application Wheat, Maize, Soybean, Sassia Seed,etc Input 3 Phase Electricity Color White Type Air Blowing Type, High Cleaning Performance Delivery Date 30 Days Warranty 1 Year Transport Package Mill`S Standard Specification ISO, SONCAP, SGS...
Product Name Current Load Relay Under-Curren 0.5~30sec Trip Time(3ez) Ground Fault Protection Contact Load Low Power Phase Reversal 0.1~0.3 Sec Phase Loss 3 Sec Over-Current O-Time Start Delay Time Setting (D-Time): 1 ~ 200 Sec Trip Time(3de) Load...
We further analyzed regressing tumors and found that pathogen response pathways are activated as early as 12 hours, followed by upregulation of a cascade of immune-related pathways associated with chemotactic-related activities (cytokine & receptors), antigen presentation (DC function), and TIL-based...
The AB-1015 DNA cassette includes two functional modules: an 'AND' logic gate targeting ALPG/P and MSLN designed to limit off-tumor toxicity through dual tumor antigen recognition, and a dual shRNA-miR targeting FAS and PTPN2 to resist TME suppression and to improve ICT cell function. The ...