The sheath has a characteristic structure, with regions densely wrapped in myelin interspersed with areas of little to no myelin (referred to as the nodes of Ranvier).In addition to neurons, the nervous system also is home to a diverse class of cells called glia, which play a number of ...
8.Gallego- Delgado, P. et al. Neuroinflammation in the normal- appearing whitematter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodesof Ranvier. PLoS Biol. 18, e3001008 (2020). 9.Schattling, B. et al. Bassoon proteinopathy drives neurodegeneration inmultiple sclerosis....
A recent study on NgR1-knockout mice (ngr1−/−) has shown that these mice exhibit re-distribution of the paranodal Caspr protein with longer nodes of Ranvier and with evidence of elevated myelin turnover [64]. This study suggests myelin plasticity in ngr1−/− mice, highlighting ...
The pathogenesis of the acute motor axonal neuropathy (AMAN) variant is mediated by complement-fixing anti-ganglioside antibodies that directly bind and injure the axon at sites of vulnerability such as nodes of Ranvier and nerve terminals. Consequently, the complement cascade is an attractive target...
For example, in future studies we can accurately measure numerous paranodal proteins found in the critical region adjacent to the Nodes of Ranvier, containing clustered ion channels and adhesion proteins, which is a vulnerable region follow- ing axonal injury or stress [71]. Electron microscopy ...
Histologically, BIN1 is mostly expressed at the Ranvier nodes. BACE1 (beta-site amyloid precursor protein cleav- ing enzyme 1) codes for a transmembrane β secretase expressed in several cell types including oligodendro- cytes. It cleaves APP giving birth to amyloid peptides, but also neuroregul...
involved in late AD behind theAPOEgene [169]. It is mainly expressed in mature oligodendrocytes and white matter in rodents and humans, where it regulates membrane dynamics in the phenomena of endocytosis and membrane remodeling [37]. Histologically,BIN1is mostly expressed at the Ranvier nodes. ...