MS: a CNS and systemic autoimmune disease. Immunol. Today 10, 104-107.HAFLEatD.A., WEIN~ H.L.: MS: a CNS and sys- temic autoimmune disease. Immunol. Today 10:104-107, 1989.Hafler DA , Weiner HL ( 1989 ): MS: A CNS and systemic autoimmune disease . Immunol Today 10 : 104 –...
These abnormalities primarily involve immunoregulatory defects in T-cell function that are associated with T- and B-cell hyperactivity. In this review, David Hafler and Howard Weiner discuss the evidence that there are T-cell abnormalities in MS similar to those observed in other autoimmune diseases...
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by oste... K Sato,A Suematsu,K Okamo...
4.Scott FL,Clemons B,Brooks J,et al.Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. Br J Pharmacol. 2016 Jun;173(11):1778-92. 5.FDA Approves Zeposia. 6.Cohan S, Lucassen E, Smoot...
[8]HauslerD, Hausser-Kinzel S, Feldmann L, et al.Functionalcharacterization of reappearing B cells after anti-CD20 treatment of CNSautoimmune disease. Proc Natl Acad Sci U S A. 2018;115: 9773–9778. 添加罕见病小助手 获取更多更新的罕见病...
aMS is a chronic, inflammatory, autoimmune disease of the central nervous system that disrupts communication between the brain and other parts of the body. It is among the most common causes of neurological disability in young adults and occurs at least twice as frequently in women as in men....
MS is an autoimmune disease that affects the brain, spinal cord, and optic nerves, while muscular dystrophy (MD) causes certain muscles to weaken over time. MD is actually a general term for a group of genetic diseases that have various levels of severity. However, they all become worse ove...
This review tries to provide an overview of the relevant literature and to summarize the current body of evidence on the role of Th17 cells in CNS autoimmune disease. 展开 关键词: Encephalomyelitis Experimental Autoimmune Morphine Sulfate Central Nervous System Autoimmune Diseases Cells *中枢神经系统 ...
多发性硬化症(multiple sclerosis, MS)是一种原发于中枢神经系统的炎症性脱髓鞘疾病。自身免疫性脑脊髓炎(EAE)模型是多发性硬化症(MS)的常用动物模型。EAE模型是一种有用的工具,可以用来研究MS的病理生理学、免疫学和治疗方法。
Multiple sclerosis (MS) is an autoimmune disease in which the body’s immune system attacks and destroys myelin, a fatty substance that covers and protects nerve fibers and is critical for the promotion of a quick and efficient transmission of nerve impulses. Without myelin, nerve communication ...