Multiple sclerosis (MS) is an autoimmune disease that usually occurs during the reproductive years in both sexes. Many male patients with MS show lower blood testosterone levels, which was also observed in male rats during experimental autoimmune encephalomyelitis (EAE), an animal model of MS. To ...
TMEM10 expression in human MS plaques MS is an autoimmune disorder in which CNS myelin is attacked by the immune system. Although OPCs in the adult CNS are initially able to differentiate and remyelinate demyelinated regions, remyelination efficiency decreases as MS progresses, likely due to ...
The Journal of Immunology, 1999, 162: 6247–6254. clinical, and immunological similarities between MS and an experimentally relapsing experimental 展开 年份: 1999 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Semantic Scholar 相似文献Suppression of Murine Chronic Relapsing Experimental Autoimmune ...
“Celiac disease is an autoimmune condition, affecting about 1% of the population, in which the immune system is triggered in response to gluten exposure, leading to gut inflammation,” explains Dr. Guy A. Weiss, director of the UCLA Celiac Disease Program and an assistant profe...
SummaryBackground Multiple sclerosis is an autoimmune disorder characterised by the repeated occurrence of demyelinating lesions within the central nervous... Franz,Fazekas,and,... - 《Lancet》 被引量: 713发表: 1997年 Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a ...
Objective: Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), provide valuable tools to examine the mechanisms contributing ...
There has been an argument that AIRE-deficient mice are infertile due to autoimmune reasons and that a Recombination activating gene (RAG)-1-KO on AIRE-KO background was fertile since T/B lymphocytes were depleted in this model (42). However, these authors did not evaluate the effect of ...
Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune encephalomyelitis (EAE), an animal model of MS; however, IFN-β is not effective in treating all cases of MS. Here, we demonstrate that signali...
(ms) 1:800 dilution (Millipore Sigma); anti-GFAP (gt) 1:800 dilution (Novus Biological); anti-GFP 1:5,000 dilution (Thermo Fisher); anti-Hsp90 1:100 dilution (Abcam); anti-Iba1 (rbt) 1:300 dilution (Wako); anti-Iba1 (gt) 1:100 dilution (Abcam); anti-MBP 1:500 dilution (...
Multiple sclerosis (MS) is a progressive autoimmune disease of the CNS with its underlying mechanisms not fully understood. In the present study, we tested the hypothesis that caveolin-1, a major membrane scaffolding protein, plays a critical role in the pathogenesis of experimental autoimmune enceph...