Multiple sclerosis (MS) is an autoimmune disease that usually occurs during the reproductive years in both sexes. Many male patients with MS show lower blood testosterone levels, which was also observed in male rats during experimental autoimmune encephalomyelitis (EAE), an animal model of MS. To ...
TMEM10 expression in human MS plaques MS is an autoimmune disorder in which CNS myelin is attacked by the immune system. Although OPCs in the adult CNS are initially able to differentiate and remyelinate demyelinated regions, remyelination efficiency decreases as MS progresses, likely due to ...
The Journal of Immunology, 1999, 162: 6247–6254. clinical, and immunological similarities between MS and an experimentally relapsing experimental 展开 年份: 1999 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Semantic Scholar 相似文献Suppression of Murine Chronic Relapsing Experimental Autoimmune ...
Objective: Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), provide valuable tools to examine the mechanisms contributing ...
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Introduction: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS with an autoimmune pathogenesis. Over the years, numerous ... C Zilli,PS Rossi,AD Stadio,... - 《Frontiers in Neurology》 被引量: 0发表: 2023年 加载更多研究...
There has been an argument that AIRE-deficient mice are infertile due to autoimmune reasons and that a Recombination activating gene (RAG)-1-KO on AIRE-KO background was fertile since T/B lymphocytes were depleted in this model (42). However, these authors did not evaluate the effect of ...
Immunogenicity and Adverse Events after Covid-19 Vaccination in Patients with Systemic Inflammatory Autoimmune Diseases BACKGROUND. The first cases of COVID-19 began in Wuhan, Hubei Province china, in December 2019. Since then, this disease caused by a highly pathogenic viru... HS Abdel-Moteleb...
Males are generally more susceptible to impaired glucose metabolism and type 2 diabetes (T2D) than females. However, the underlying mechanisms remain to be determined. Here, we revealed that gut microbiome depletion abolished sexual dimorphism in glucose
Multiple sclerosis (MS) is a progressive autoimmune disease of the CNS with its underlying mechanisms not fully understood. In the present study, we tested the hypothesis that caveolin-1, a major membrane scaffolding protein, plays a critical role in the pathogenesis of experimental autoimmune enceph...