Eliane Hajnsdorf, et al. RNA polyadenylation and its consequences in prokaryotes. Philos Trans R Soc Lond B Biol Sci. 2018 Nov 5;373(1762):20180166. Hanhan Shi, et al. Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and tra...
DNA需要转化为蛋白质才能够将遗传信息表达出来。 整个DNA转化为蛋白质的过程分为两大步,第一步:DNA转化为mRNA,这一步骤称为转录(transcription),发生在细胞核内;第二步:mRNA转化为蛋白质,这一步骤称为转译(translation),发生在细胞质中。 具体来分析mRNA新冠疫苗的机理。mRNA疫苗中的mRNA片段编码新冠病毒表面的某些...
Eliane Hajnsdorf, et al. RNA polyadenylation and its consequences in prokaryotes. Philos Trans R Soc Lond B Biol Sci. 2018 Nov 5;373(1762):20180166. Hanhan Shi, et al. Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and tra...
Transcription and mRNA turnover determine the quantitative composition of the cellular transcriptome. The transcriptome in turn serves as a template for the proteome via translation. Treatment ofSaccharomyces cerevisiaewith the TOR kinase inhibitor rapamycin causes increases and decreases in the mRNA levels ...
[19]Interplay of mRNA capping and transcription machineries. [20]Improved translation efficiency of therapeutic mRNA. 3.mRNA疫苗递送系统 [21]Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines [22]Efficiency of Chitosan...
Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose. Here, we sought for a possible connection bet...
事实上,EJC会被一同带出细胞核,如果翻译机器发现mRNA有异常,比如终止密码子出现得太早了(称为提前终止密码子(premature translation termination codon, PTC))——那么RBM8A将会引发无义介导的mRNA降解(nonsense-mediated mRNA decay, NMD,让人魔怔的名字)机制。EJC在细胞核内时,会结合UPF2(Up-frameshift suppressor ...
The process of gene expression is divided into translation and transcription. Considerable efforts have been made in bacteria to characterize the mechanisms underlying translational regulation and identify the regulatory factors for particular mRNAs. ABSTRACT Translational regulation was investigated at the ...
5' Cap保护mRNA不被外切酶降解，与3'端的poly A尾、poly A结合蛋白（PAPB）和翻译起始因子蛋白协同作用，起始蛋白质的翻译。体外转录（In Vitro Transcription，IVT）的加帽是常用的加帽方式，可以在IVT时加帽（即共转录加帽），也可以在IVT结束后加帽（即酶法加帽）【详见mRNA体外制备之酶法加帽和共转录加帽...
(1992) Interdependence of translation, transcription and mRNA degradation in the lacZ gene. J Mol Biol 226: 581- 596.Yarchuk, O., Jacques, N., Guillerez, J. and Dreyfus, M.: Interdependence of translation, transcription and mRNA degrada- tion in the lacZ gene. J. Mol. Biol. 226 (...