mRNA疫苗设计和制备: A plasmid encoding the RNA polymerase promoter followed byhAg 5’UTR, with optimized Kozak sequence, and ORF,hAg 3’UTR, and120nt poly(A)tail were synthesized. The ORF coding for KRAS G12V neo-a...
在mRNA递送领域,多种含胺基的聚酯已被开发用于mRNA递送,包括聚(β-氨基酯)[poly(β-aminoester),PBAEs,4]、氨基聚酯(amino polyester,APEs)和电荷改变释放转运体(charge-altering releasable transporters,CARTs,5和6)等。其中,PBAEs 是经典...
S. (1993) Enhanced mRNA content in response to amino acid starvation for a 73 kDa protein of the inner mitochondrial membrane. Biochem. Biophys. Res. Commun. 193, 1068-1075ChilesTC, LaineRO, Shay NF, Handlogten ME, Nick HS, Kilberg MS: Enhanced mRNA contentin responseto aminoacid ...
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and treatment of a wide range of diseases. The recent success of the two highly efficacious mRNA vaccines produced by Moderna and Pfizer–BioNTech to protect against COVID-
5. Brenner, S., F. Jacob, and M. Meselson, An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature, 1961. 190: p. 576-581. 6. Gros, F., et al., Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli. Nature, 1961. 190:...
The acid dissociation constant, a quantitative measurement of the strength of a chemical group as an acid in solution. It corresponds to the pH value at which half of the ionizable group is either protonated or deprotonated. ε-amino group A positively charged group found at the extremity of ...
the mRNA and the amino acid sequence of proteins.tRNA does this by carrying an amino acid to ...
(3)By virtue of its length or amino acid composition, it allows the clearest description of ...
An mRNA molecule consists of a single-stranded ribonucleic acid that carries coding information for the translation and processing of functional proteins [141,164]. Early studies on mRNA showed that the molecules can also play multifunctional roles in regulating gene function [245]. Due to its pote...
The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. ...