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We used RNAcompete to enumerate the RNA-binding preference of human AGO2 to all possible 7-mer RNA sequences and validated the AGO motif in vitro. These findings reveal a novel function of AGOs as sequence-specific RNA-binding proteins, which may aid miRNAs in recognizing their targets with ...
Then we could actually treat their disease instead of just managing their symptoms. And that's where mRNA comes in. That's also where I come in. You see, I spent the better part of my career as an academic doing curiosity-based research into the f...
Indeed, both purified proteins bound preferentially to RNA sequences containing GAA repeats, characteristic of many enhancer elements. Neither Tra2 protein functioned in constitutive splicing in vitro, but both activated enhancer-dependent splicing in a sequence-specific manner and restored it after ...
Small segments of DNA are transcribed into RNA by theenzymeRNA polymerase, which achieves this copying in a strictly controlled process. The first step is to recognize a specific sequence on DNA called a promoter that signifies the start of the gene. The two strands of DNA become separated at...
F. & Jaffrey, S. R. Reading m6A in the transcriptome: m6A-binding proteins. Trends Cell Biol. 28, 113–117 (2017). Kennedy, E. M. et al. Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe 19, 675–685 (2016). Article CAS PubMed ...
some curable with specific treatments, and all exhibiting different patterns of protein expression. Therefore, classifying cancers by their proteomes (a proteome consists of all proteins expressed in a given cell or tissue) promises a prognosis for individual patients based not on the location of the...
remains unclear how either protein mechanistically contributes to splicing regulation and whether these proteins co-regulate additional splicing events in a similar manner. Here we use a combination of biochemistry, cell biology, and mutant viruses to identify new regulatory sequences controlling M1 to ...
Distinct mRNA-binding proteins interacting with short repeat sequences of the 3' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene, Cas-1. Reimer DL, Singh SM (1996) Distinct mRNA-binding proteins interacting with short repeat sequences of the 3' UTR may ...
(SGP). Within the 5′-and 3′-UTRs, one can find viral conserved sequence elements (CSEs), which are responsible for specific RNA amplification by alphavirus replicase [209] (Fig.1B). Since the length of saRNAs is larger than 10 kb and encapsulation efficiencies of large mRNAs are low...