CD117抗体偶联LNP递送Cre mRNA 题目:In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles 期刊:Nano Letters【影响因子9.6】 链接:pubmed.ncbi.nlm.nih.gov/36988645/ Daniel G. Anderson...
Cat.No.Product NamePrice RNTK-001 mRNA in vitro transfection kit Inquiry RNTK-002 mRNA in vivo delivery kit Inquiry References: Islam M.A., et al. (2015). Biomaterials for mRNA delivery. Biomaterials science, 3(12), 1519-1533. Steinle H., et al. (2017). Concise review: application...
Functional delivery of mRNA has high clinical potential. Previous studies established that mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles (LNPs). Here we describe an alternative approach using exosomes, the only biologically normal nanovesicle. In contrast ...
Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein is a potential regenerative factor for cartilage repair. However, traditional protein delivery methods have limited efficacy due to the short lifetime a
which encodes a critical effector protein to induce EMT and metastasis. Importantly, in vivo delivery of PEI-coated circITGB6 siRNA complex dramatically suppresses liver metastasis and extends survival of mice suffering liver metastasis. Our findings indicate circITGB6 as a pivotal TGFβ effector and...
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxi
Liver transaminases and blood urea nitrogen (BUN) trended toward normal unaffected levels in dual mRNAs-treated mice. A prior limitation of polyethylene glycolated (PEGylated) lipid-delivery systems has been the induction of accelerated blood clearance of the LNPs partly due to the formation of ...
As such, NLPs provide a number of possible benefits as a delivery platform for mRNA molecules: 1) facile tailoring of NLP physicochemical parameters (e.g. charge, charge density, size) provides a rich pool of candidates to enhance in vivo delivery, 2) increased surface area and smaller size...
In addition, CRISPR-Cas9 genome editing using Cas9 mRNA has been cited for use with microinjections and otherin vivo-mediated delivery methods for transgenic model system generation in a wide variety of organisms, including mice [1], zebrafish [2], andDrosophila. For microinjection experiments and...
However, mRNA therapy is still facing the challenge of lacking safe and effective delivery system, because the large size and dense negative charge make naked mRNA difficult to pass through the cell membrane. In addition, mRNA is also an inherently unstable molecule that is susceptible to degradati...